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Study of auditory cortex function and frequency map in mice using flavoprotein fluorescence imaging

Research Project

Project/Area Number 23791882
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionNiigata University

Principal Investigator

KUBOTA Yamato  新潟大学, 医歯学総合病院, 助教 (40547593)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords聴覚医学 / 中枢聴覚 / イメージング / 大脳聴覚野 / 周波数マップ / 中枢性耳鳴 / 耳鳴
Research Abstract

We studied the cerebral auditory cortex function in mice using flavoprotein fluorescence imaging method.As a result,we got the following findings.1:After continuous tonal sonud exposure,On and Off responces in A1 were strongly observed.2:Changing the direction of frequency modulation of stimuli,specific reactions were observed at UF and DP area.It had been projected from the site that is different from the primary auditory cortex in the medial geniculate body.3:Age-related hearing loss mouse,there was no apparent change in the auditory cortex map in moderate hearing loss.Activities in midrange stimuli had become strong when it comes to severe hearing loss.4:In both sides measurement,strong responces were observed in the contralateral auditory cortex of the stimulus side in the auditory cortex.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2014 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (19 results)

  • [Journal Article] Auditory cortical areas activated by slow frequency-modulated sounds in mice2013

    • Author(s)
      Honma Y, Tsukano H, Horie M, Ohshima S, Tohmi M, Kubota Y, Takahashi K, Hishida R, Takahashi S, Shibuki K
    • Journal Title

      PLoS One

      Volume: 8(7)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] マウス聴覚・視覚連想記憶のM字迷路による解析2014

    • Author(s)
      山岸達也、塚野浩明、馬場洋徳、本間悠介、大島伸介、窪田和、高橋邦行、髙橋姿、澁木克栄
    • Organizer
      第91回日本生理学大会
    • Place of Presentation
      鹿児島大学郡元キャンパス
    • Year and Date
      2014-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス聴覚・視覚連想記憶のM字迷路による解析2014

    • Author(s)
      山岸達也、塚野浩明、馬場洋徳、本間悠介、大島伸介、窪田和、高橋邦行、髙橋姿、澁木克栄
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス聴覚・視覚連想記憶のM字迷路による解析2013

    • Author(s)
      山岸達也、馬場洋徳、本間悠介、大島伸介、窪田和、高橋邦行、澁木克栄、髙橋姿
    • Organizer
      第18回聴覚研究フォーラム
    • Place of Presentation
      同志社びわこリトリートセンター
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Cortical depression in the mouse auditory cortex after sound discrimination learning2013

    • Author(s)
      S.Ohshima, K.Takahashi, T.Yamagishi, H.Baba, Y.Honma, H.Tsukano, Y.Kubota, R.Hishida, K.Shibuki, S.Takahashi
    • Organizer
      The 29^<th> Politzer Society Meeting
    • Place of Presentation
      Susesi Resort - Antalya, Turkey
    • Year and Date
      2013-11-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Bilateral functional differences in the mouse auditory cortex using flaboprotein autofluoresence imaging2013

    • Author(s)
      K.Takahashi, H.Baba, Y.Honma, S.Ohshima, Y.Kubota, S.Takahashi
    • Organizer
      2^<nd> Meeting of European Academy of ORL-HNS
    • Place of Presentation
      Nice, France
    • Year and Date
      2013-04-27
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス聴覚野OFF反応のイメージング解析2013

    • Author(s)
      馬場洋徳、塚野浩明、本間悠介、大島伸介、窪田和、高橋邦行、澁木克栄、髙橋姿
    • Organizer
      第11回側頭骨疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-01-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Bilateral functional differences in the mouse auditory cortex using flavoprotein autofluoresence imaging2013

    • Author(s)
      K.Takahashi, H.Baba, Y.Honma, S.Ohshima, Y.Kubota, S.Takahashi
    • Organizer
      2nd Meeting of European Academy of ORL-HNS
    • Place of Presentation
      Nice, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cortical depression in the mouse auditory cortex after sound discrimination learning2013

    • Author(s)
      S.Ohshima, K.Takahashi, T.Yamagishi, H.Baba, Y.Honma, H.Tsukano, Y.Kubota, R.Hishida, K.Shibuki, S.Takahashi
    • Organizer
      The 29th Politzer Society Meeting
    • Place of Presentation
      Antalya, Turkey
    • Related Report
      2013 Annual Research Report
  • [Presentation] 先行音持続刺激により出現するマウス聴覚野の二相性応答パターン2012

    • Author(s)
      馬場洋徳、本間悠介、大島伸介、窪田和、高橋邦行、澁木克栄、髙橋姿
    • Organizer
      第57回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2012-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス聴覚野における二相性ON-OFF応答の持続刺激後の出現2012

    • Author(s)
      馬場洋徳、塚野浩明、本間悠介、大島伸介、窪田和、高橋邦行、菱田竜一、髙橋姿、澁木克栄
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス大脳聴覚野の周波数変調(FM)音処理機構2012

    • Author(s)
      本間悠介、高橋邦行、塚野浩明、堀江正男、馬場洋徳、大島伸介、窪田和、澁木克栄、髙橋姿
    • Organizer
      第113回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      新潟,朱鷺メッセ
    • Year and Date
      2012-05-10
    • Related Report
      2013 Final Research Report
  • [Presentation] ON and OFF responses in the mouse auditory cortex after exposure to long-lasting tone bursts2012

    • Author(s)
      馬場洋徳、塚野浩明、本間悠介、大島伸介、窪田和、高橋邦行、菱田竜一、髙橋姿、澁木克栄
    • Organizer
      第89回日本生理学大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      2012-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス大脳聴覚野におけるFM音情報処理領域2012

    • Author(s)
      本間悠介, 高橋邦行, 塚野浩明, 堀江正男, 馬場洋徳, 大島伸介, 窪田和, 澁木克栄, 高橋姿
    • Organizer
      第10回側頭骨疾患研究会
    • Place of Presentation
      仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] ON and OFF responses in the mouse auditory cortex after exposure to long-lasting tone bursts2012

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 菱田竜一, 高橋姿, 澁木克栄
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Related Report
      2011 Research-status Report
  • [Presentation] ON and OFF responses in the mouse auditory cortex disclosed after sound exposure2011

    • Author(s)
      馬場洋徳、塚野浩明、本間悠介、大島伸介、窪田和、高橋邦行、菱田竜一、髙橋姿、澁木克栄
    • Organizer
      第16回聴覚研究フォーラム
    • Place of Presentation
      同支社びわこリトリートセンター
    • Year and Date
      2011-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] ON and OFF responses in the mouse auditory cortex disclosed after sound exposure2011

    • Author(s)
      馬場洋徳, 塚野浩明, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 菱田竜一, 高橋姿, 澁木克栄
    • Organizer
      第16回聴覚研究フォーラム
    • Place of Presentation
      滋賀
    • Related Report
      2011 Research-status Report
  • [Presentation] 先行持続音刺激により出現するマウス聴覚野の二相性応答パターン

    • Author(s)
      馬場洋徳、本間悠介、大島伸介、窪田和、高橋邦行、澁木克栄、髙橋姿
    • Organizer
      第57回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス聴覚野における二相性ON-OFF応答の持続音刺激後の出現

    • Author(s)
      馬場洋徳、塚野浩明、本間悠介、大島伸介、窪田和、高橋邦行、菱田竜一、髙橋姿、澁木克栄
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス大脳聴覚野の周波数変調(FM)音処理機構

    • Author(s)
      本間悠介、高橋邦行、塚野浩明、堀江正男、馬場洋徳、大島伸介、窪田和、澁木克栄、髙橋姿
    • Organizer
      第113回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      新潟朱鷺メッセ
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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