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Candidate gene association study of Menials' disease

Research Project

Project/Area Number 23791887
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionShinshu University

Principal Investigator

FUKUOKA Hisakuni  信州大学, 医学部附属病院, 助教 (90419391)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords耳科学 / 平衡医学 / メニエール病 / 内耳 / 内リンパ水腫 / SNPs / 遺伝相関解析 / 低音障害型難聴 / 遺伝子 / ゲノム相関解析
Research Abstract

Meniere’s disease (MD) is an idiopathic disorder of the inner ear characterized by fluctuating sensorineural hearing loss (SNHL), tinnitus, aural fullness, and recurrent spontaneous episodic rotational vertigo. Meniere’s disease has been thought to be attributable to endolymphatic hydrops (ELH), but the mechanism of the endolymphatic hydrops was unknown. Mane genes, like water channel or potassium ion channel was reported to associate with Meniere’s disease but there was small amount of patients were analyzed in these reports. In this study, we performed gene association study with 200 Meniere’s disease patients and 100 control. In first screening we identified 5 significantly associated SNPs but all of them did not associate significantly in second screening.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (11 results)

  • [Journal Article] Comparison of the diagnostic value of 3 T MRI after intratympanic injection of GBCA, electrocochleography, and the glycerol test in patients with Meniere' s disease2012

    • Author(s)
      Fukuoka H, Takumi Y, Tsukada K, Miyagawa M, Oguchi T, Ueda H, Kadoya M, Usami S
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Issue: 2 Pages: 141-5

    • DOI

      10.3109/00016489.2011.635383

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 3T-MRI を用いた内リンパ水腫の診断2012

    • Author(s)
      福岡久邦
    • Organizer
      第8回信越耳鼻咽喉科セミナー
    • Place of Presentation
      白馬
    • Year and Date
      2012-03-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Comparison of the diagnostic value of 3T-MRI after intratympanic injection of GBCA in patients with Meniere's disease.2012

    • Author(s)
      Fukuoka H,Takumi Y,Miyagawa M,Oguchi T,Usami S,Ueda H, Kadoya M
    • Organizer
      27th Barany Society Meeting
    • Place of Presentation
      Uppsala,Sweden
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Comparison of the diagnostic value of 3T-MRI after intratympanic injection of GBCA, electrocochleography, and glycerol test in patients with Meniere's disease2012

    • Author(s)
      Fukuoka H
    • Organizer
      The 14th Japan-Krea Joint Meeting
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Comparison of the diagnostic value of 3T-MRI after intratympanic injection of GBCA, electrocochleography, and glycerol test in patients with Meniere's disease2012

    • Author(s)
      Hisakuni Fukuoka
    • Organizer
      The 14th Japan-Krea Joint Meeting
    • Place of Presentation
      京都ホテルおおくら
    • Related Report
      2012 Annual Research Report
  • [Presentation] 難治性内耳疾患の遺伝子バンクプロジェクトの現況(メニエール病患者におけるSNPs関連解析)2012

    • Author(s)
      福岡久邦、西尾信哉、塚田景大、宇佐美真一、渡辺行雄
    • Organizer
      前庭機能異常に関する調査研究班会議
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 3T-MRIによる内リンパ水腫の評価を経時的に行った症例についての検討2012

    • Author(s)
      福岡久邦、工 穣、宮川麻衣子、塚田景大、宇佐美真一
    • Organizer
      前庭機能異常に関する調査研究班会議
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 画像により、イソソルビドの内リンパ水腫軽減効果を確認できた 1 例2011

    • Author(s)
      福岡久邦、工 穣、宮川麻衣子、塚田景太、宇佐美真一
    • Organizer
      第70回日本めまい平衡医学会総会
    • Place of Presentation
      ニューオータニ幕張
    • Related Report
      2012 Final Research Report
  • [Presentation] メニエール病の診断における3T-MRI の有用性2011

    • Author(s)
      福岡久邦、工 穣、宮川麻衣子、塚田景太、小口智啓、宇佐美真一
    • Organizer
      第73回耳鼻咽喉科臨床学会
    • Place of Presentation
      松本
    • Related Report
      2012 Final Research Report
  • [Presentation] 眼振表記の標準化を目指した電子カルテ上での3次元眼球運動画像解析(3D-VOG)半自動化の試み2011

    • Author(s)
      工 穣、池田卓生、  福岡久邦、塚田景大、小口智啓、沖野正二、吉田眞也、宇佐美真一
    • Organizer
      Videoカメラによる眼運動記録解析に関するワークショップ
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] メニエール病の診断における3T-MRIの有用性2011

    • Author(s)
      福岡久邦、工 穣、宮川麻衣子、塚田景太、小口智啓、宇佐美真一
    • Organizer
      第73回耳鼻咽喉科臨床学会
    • Place of Presentation
      松本
    • Related Report
      2011 Research-status Report
  • [Presentation] 画像により、イソソルビドの内リンパ水腫軽減効果を確認できた1例2011

    • Author(s)
      福岡久邦、工 穣、宮川麻衣子、塚田景太、  宇佐美真一
    • Organizer
      第70回日本めまい平衡医学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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