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Evaluation of the diagnostic value of 3T-MRI intratympanic injection of GBCA for Menieres disease

Research Project

Project/Area Number 23791889
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionShinshu University

Principal Investigator

MIYAGAWA Maiko  信州大学, 医学部, 委嘱講師 (60467165)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords耳科学 / メニエール病 / MRI / 画像診断 / 内リンパ水腫 / 前庭機能
Research Abstract

To investigate the relationship between 3T MRI after intratympanic injection of GBCA, the glycerol test, and ECoG in patients with Menieres disease (MD). A total of 20 patients with MD were evaluated. Diluted gadodiamide (a gadolinium-based contrast agent) was administered to the bilateral tympanic cavity by injection through the tympanic membrane. After 24 h, the endolymphatic hydrops was evaluated by a 3.0 T MR scanner. To investigate cochlear hydrops, the glycerol test and ECoG were carried out in all patients. As a esults a positive result was observed in 11 patients (55%) in the glycerol test and in 12 patients (60%) by ECoG. The incidence of positive findings when evaluating the same patients with both the glycerol test and ECoG increased to 75%. Nineteen of 20 (95%) patients showed positive results for 3T MRI.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results)

  • [Journal Article] Comparison of the diagnostic value of 3 T MRI after intratympanic injection of GBCA, electrocochleography, and the glycerol test in patients with Meniere's disease2012

    • Author(s)
      Fukuoka H, Takumi Y, Tsukada K, Miyagawa M, Oguchi T, Ueda H, Kadoya M, Usami S
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Pages: 141-5

    • NAID

      120007110632

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the diagnostic value of 3 T MRI after intratympanic injection of GBCA, electrocochleography, and the glycerol test in patients with Meniere' s disease2012

    • Author(s)
      Fukuoka H, Takumi Y, Tsukada K, Miyagawa M, Oguchi T, Ueda H, Kadoya M, Usami S
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Issue: 2 Pages: 141-5

    • DOI

      10.3109/00016489.2011.635383

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] MRIによる内リンパ水腫画像診断〜治療効果の評価〜2013

    • Author(s)
      福岡久邦、工穣、吉村豪兼、宮川麻衣子、塚田景大、宇佐美真一
    • Organizer
      第72回日本めまい平衡医学会
    • Place of Presentation
      大阪国際交流センター
    • Related Report
      2013 Final Research Report
  • [Presentation] 3T-MRIにて診断し得た小児発症一側難聴による遅発性内リンパ水腫の一例2013

    • Author(s)
      森健太郎、塚田景大、岩佐陽一郎、吉村豪兼、福岡久邦、宇佐美真一
    • Organizer
      第72回日本めまい平衡医学会
    • Place of Presentation
      大阪国際交流センター
    • Related Report
      2013 Final Research Report
  • [Presentation] MRIによる内リンパ水腫画像診断~治療効果の評価~2013

    • Author(s)
      福岡久邦、工 穣、吉村豪兼、宮川麻衣子、塚田景大、宇佐美真一
    • Organizer
      第72回日本めまい平衡医学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] メニエール病非定型例(蝸牛型)に対する3T-MRIの検討2012

    • Author(s)
      岩佐陽一郎、福岡久邦、工穣、吉村豪兼、塚田景大、宇佐美真一
    • Organizer
      第71回日本めまい平衡医学会総会
    • Place of Presentation
      学術総合センター(東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of the diagnostic value of 3T-MRI after intratympanic injection of GBCA in patients with Meniere's disease2012

    • Author(s)
      Fukuoka H, Takumi Y, Miyagawa M, Oguchi T, Usami S, Ueda H, Kadoya M
    • Organizer
      27th Barany Society Meeting
    • Place of Presentation
      Uppsala,Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of the diagnostic value of 3T-MRI after intratympanic injection of GBCA, electrocochleography, and glycerol test in patients with Meniere's disease2012

    • Author(s)
      Fukuoka H, Takumi Y, Miyagawa M, Oguchi T, Usami S
    • Organizer
      The 14th Japan-Krea Joint Meeting
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of the diagnostic value of 3T-MRI after intratympanic injection of GBCA in patients with Meniere's disease.2012

    • Author(s)
      Fukuoka H,Takumi Y,Miyagawa M,Oguchi T,Usami S,Ueda H, Kadoya M.
    • Organizer
      27th Barany Society Meeting
    • Place of Presentation
      Uppsala,Sweden
    • Related Report
      2012 Research-status Report
  • [Presentation] 3T-MRIによる内リンパ水腫の評価を経時的に行った症例についての検討2012

    • Author(s)
      福岡久邦、工 穣、宮川麻衣子、塚田景大、宇佐美真一
    • Organizer
      前庭機能異常に関する調査研究班会議
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 画像により、イソソルビドの内リンパ水腫軽減効果を確認できた1例2011

    • Author(s)
      福岡久邦、工穣、宮川麻衣子、塚田景太、宇佐美真一
    • Organizer
      第70回日本めまい平衡医学会総会
    • Place of Presentation
      ニューオータニ幕張
    • Related Report
      2013 Final Research Report
  • [Presentation] 画像により、イソソルビドの内リンパ水腫軽減効果を確認できた1例2011

    • Author(s)
      福岡久邦、工 穣、宮川麻衣子、塚田景太、宇佐美真一
    • Organizer
      第70回日本めまい平衡医学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] メニエール病の診断における3T-MRIの有用性2011

    • Author(s)
      福岡久邦、工 穣、宮川麻衣子、塚田景太、小口智啓、宇佐美真一
    • Organizer
      第73回耳鼻咽喉科臨床学会
    • Place of Presentation
      松本
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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