Mucosal immune response associated with NKT cell activation innasopharyx for the development of prospective mucosal vaccine

• Project/Area Number: 23791909
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Oita University
• Principal Investigator: NODA Kenji 大分大学, 医学部耳鼻咽喉科, 助教 (90511171)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: NKT細胞 / a-ガラトクトシルセラミド / 経鼻免疫 / 中耳炎予防ワクチン / P6 / α-galactosylceramide / 粘膜免疫

Research Abstract

Specific IgA plays an important role in the elimination of pathogen.In this study, we demonstrated that CD4+T cells expressing P6-specific Th1 and Th2cytokine mRNA, which is important for the induction of the specific S-IgA immune response,were induced after intranasal immunization with P6 and α－GalCer. These findings suggestthat nasal vaccination with P6 and α-GalCer might be an effective regimen for mucosalvaccine.

Research Products

• [Journal Article] Th17 cells contribute to nontypeable Haemophilus influenzae-specific protective immunity induced by nasal vaccination with P6 outer membrane protein and alfa-galactosylceramide (2011)
  • Author(s): Noda K, Kodama S, Umemoto S, Nomi N, Hirano T, Suzuki M
  • Journal Title: Microbiol Immunol Volume: 55(8) Pages: 574-581
• [Journal Article] Th17 cells contribute to nontypeable Haemophilus influenzae-specific protective immunity induced by nasal vaccination with P6 outer membrane protein and alfa-galactosylceramide (2011)
  • Author(s): Kenji Noda
  • Journal Title: Microbiology and Immunology Volume: 55 Pages: 574-581
  • Peer Reviewed
• [Presentation] Nasal vaccination with α-galactosylceramide induces protective immunity against nontypeable Haemophilus influenzae associated with NKT cell activation in the nasopharynx (2012)
  • Author(s): Noda K
  • Organizer: ISIAN
  • Place of Presentation: France
  • Year and Date: 2012-06-17
• [Presentation] Nasal vaccination with α-galactosylceramide induces protective immunity against nontypeable Haemophilus influenzae associated with NKT cell activation in the nasopharynx. (2012)
  • Author(s): 野田謙二
  • Organizer: International Symposium on Infection and Allergy of the Nose.
  • Place of Presentation: フランス