Development of new anti-Acanthoamoeba treatment with nanotechnology.

Research Project

Project/Area Number	23791959
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	Tohoku University
Principal Investigator	YOKOKURA Shunji 東北大学, 病院, 講師 (30400378)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	アカントアメーバ / ナノテクノロジー
Research Abstract	The Ag nanoparticles were significantly more effective than Chlorhexidine gluconate for anti-trophozoite of Acanthoamoeba medication. These particles tended to be more effective than Chlorhexidine gluconate for anti-cyst of Acanthoamoeba medication. Electron microscope analysis showed that these particles were taken in not only trophozoite but also cyst. MPS containing Ag nanoparticles manifested significant effectiveness of anti-trophozoite and anti-cyst of Acanthoamoeba.