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Development of sutureless keratoplasty using femtosecond laser

Research Project

Project/Area Number 23791982
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

SOMA Takeshi  大阪大学, 医学(系)研究科(研究院), 特任助教(常勤) (70582401)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords角膜移植 / フェムトセカンドレーザー
Research Abstract

We investigated sutureless penetrating keratoplasty (PK) using femtosecond laser (FSL) in rabbit. No inflammatory cell was observed in corneal tissues after zig-zag, top-hat, and mushroom incision using FSL both in normal and bullous keratopathy model rabbit. Each donor was transplanted to recipient donors with fewer sutures compared to conventional PK. Screw configuration using FSL might be useful for sutureless PK.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (54 results)

All 2014 2013 2012 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (34 results) (of which Invited: 3 results) Book (12 results)

  • [Journal Article] Development of a Cell Sheet Transportation Technique for Regenerative Medicine2013

    • Author(s)
      Oie Y, Nozaki T, Takayanagi H, Hara S, Hayashi R, Takeda S, Mori K, Moriya N, Soma T, Tsujikawa M, Saito K, Nishida K
    • Journal Title

      Tissue Eng Part C Methods

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Instillation of Dry Eye Drops on Optical Quality2013

    • Author(s)
      Koh S, Maeda N, Ikeda C, Takai Y, Fujimoto H, Oie Y, Soma T, Tsujikawa M, Nishida K
    • Journal Title

      Invest Ophthalmol Vis Sci

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interface fluid syndrome after laser in situ keratomileusis following herpetic keratouveitis2013

    • Author(s)
      Goto S, Koh S, Toda R, Soma T, Matsushita K, Maeda N, Nishida K
    • Journal Title

      J Cataract Refract Surg

      Volume: 39 Pages: 1267-1270

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Cell Sheet Transportation Technique for Regenerative Medicine.2013

    • Author(s)
      Oie Y, Nozaki T, Takayanagi H, Hara S, Hayashi R, Takeda S, Mori K, Moriya N, Soma T, Tsujikawa M, Saito K, Nishida K.
    • Journal Title

      Tissue Eng Part C Methods.

      Volume: Epub

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Instillation of Dry Eye Drops on Optical Quality.2013

    • Author(s)
      Koh S, Maeda N, Ikeda C, Takai Y, Fujimoto H, Oie Y, Soma T, Tsujikawa M, Nishida K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: Epub Issue: 7 Pages: 4927-4933

    • DOI

      10.1167/iovs.13-12409

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interface fluid syndrome after laser in situ keratomileusis following herpetic keratouveitis.2013

    • Author(s)
      Goto S, Koh S, Toda R, Soma T, Matsushita K, Maeda N, Nishida K.
    • Journal Title

      J Cataract Refract Surg.

      Volume: 39 Issue: 8 Pages: 1267-1270

    • DOI

      10.1016/j.jcrs.2013.04.026

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of methicillin-resistant Staphylococcus aureus keratitis in a dry eye patient with a therapeutic contact lens2012

    • Author(s)
      Koh S, Maeda N, Soma T, Hori Y, Tsujikawa M, Watanabe H, Nishida K
    • Journal Title

      Eye Contact Lens

      Volume: 38 Pages: 200-202

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 円錐角膜における光干渉断層計トポグラファーによる角膜形状解析と装用コンタクトレンズベースカーブとの関係2012

    • Author(s)
      中川智哉, 前田直之, 東浦律子, 相馬剛至,高静花, 辻川元一, 大鳥安正, 西田幸二
    • Journal Title

      日本コンタクトレンズ学会誌

      Volume: 54 Pages: 159-164

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 生体適合性架橋剤を用いた角膜実質疾患治療の開発2014

    • Author(s)
      相馬剛至
    • Organizer
      第5回UAC霧島眼科研鑚会
    • Place of Presentation
      都城
    • Year and Date
      2014-02-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体適合性架橋剤とフェムト秒レーザーを用いた菲薄化角膜に対する角膜実質再生治療2014

    • Author(s)
      相馬剛至、松崎典弥、松本匡広、辻川元一、林竜平、大家義則、網代広治、明石満、西田幸二
    • Organizer
      角膜カンファランス2014
    • Place of Presentation
      宜野湾
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 教育セミナー・角膜全層移植の基本手技「術後管理」2014

    • Author(s)
      相馬剛至
    • Organizer
      第37回日本眼科手術学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体適合性架橋剤を用いた角膜実質疾患治療の開発.2014

    • Author(s)
      相馬剛至
    • Organizer
      第5回UAC霧島眼科研鑚会
    • Place of Presentation
      都城
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 角膜全層移植の基本手技 「術後管理」2014

    • Author(s)
      相馬剛至
    • Organizer
      第37回日本眼科手術学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 角膜移植アップデート2013

    • Author(s)
      相馬剛至、西田幸二
    • Organizer
      第235回OCC
    • Place of Presentation
      大阪
    • Year and Date
      2013-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己免疫に関連した角膜疾患-Mooren潰瘍、サイトメガロウイルス角膜内皮炎2013

    • Author(s)
      相馬剛至
    • Organizer
      第9回武庫川眼科アカデミー
    • Place of Presentation
      武庫川
    • Year and Date
      2013-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体適合性架橋剤とフェムトセカンドレーザーを用いた新規の角膜実質再生治療法2013

    • Author(s)
      相馬剛至、松崎典弥、松本匡広、辻川元一、林竜平、大家義則、網代広治、明石満、西田幸二
    • Organizer
      日本バイオマテリアル学会 第8回関西若手研究発表会
    • Place of Presentation
      大阪
    • Year and Date
      2013-08-31
    • Related Report
      2013 Final Research Report
  • [Presentation] フェムトセカンドレーザーの眼科領域への応用2013

    • Author(s)
      相馬剛至
    • Organizer
      GKK
    • Place of Presentation
      大阪
    • Year and Date
      2013-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 眼の再生医療2013

    • Author(s)
      相馬剛至
    • Organizer
      伊丹市医師会学術講演会
    • Place of Presentation
      伊丹
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium : Bioengineered Stroma Using a New Biocompatible Cross Linker2013

    • Author(s)
      Soma T
    • Organizer
      TERMIS-AP 2013
    • Place of Presentation
      Shanghai, Wuzhen, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Efficacy of a novel bioengineered corneal stroma fabricated by a new biocompatible cross linker in corneal stromal disease model2013

    • Author(s)
      Soma T, Matsusaki M, Ajiro H, Tsujikawa M, Hayashi R, Oie Y, Akashi M, Nishida K
    • Organizer
      ARVO 2013
    • Place of Presentation
      Seattle, the United States of America
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium : Bioengineered Stroma Using a New Biocompatible Cross Linker2013

    • Author(s)
      Soma T
    • Organizer
      28th Asia Pacific Academy of Ophthalmology
    • Place of Presentation
      Hyderabad, India
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium : Retention and distribution of epithelial stem and progenitor cells following corneal reconstruction with oral mucosal cell sheets2013

    • Author(s)
      Soma T
    • Organizer
      28th Asia Pacific Academy of Ophthalmology
    • Place of Presentation
      Hyderabad, India
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規に開発したグラフトインサーターを用いた角膜内皮移植の短期成績2013

    • Author(s)
      相馬剛至、藤本久貴、大家義則、中尾武史、高静花、辻川元一、川崎諭、前田直之、西田幸二
    • Organizer
      第67回臨床眼科学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 前眼部光干渉断層計を用いた治療用コンタクトレンズ眼におけるsag値と脱落の関係2013

    • Author(s)
      相馬剛至、渡辺真矢、洲崎朝樹、藤本久貴、大家義則、高静花、辻川元一、前田直之、西田幸二
    • Organizer
      第56回日本コンタクトレンズ学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己免疫に基づく角膜およびその関連疾患の最前線Mooren潰瘍2013

    • Author(s)
      相馬剛至
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体適合性架橋剤とアテロコラーゲンを用いた角膜実質の再生2013

    • Author(s)
      相馬剛至
    • Organizer
      角膜カンファランス2013
    • Place of Presentation
      和歌山
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規に開発したグラフトインサーターを用いた角膜内皮移植の2症例2013

    • Author(s)
      相馬剛至、藤本久貴、大家義則、高静花、辻川元一、前田直之、西田幸二
    • Organizer
      角膜カンファランス2013
    • Place of Presentation
      和歌山
    • Related Report
      2013 Final Research Report
  • [Presentation] 教育セミナー・角膜移植の基本手技「早期・晩期合併症」2013

    • Author(s)
      相馬剛至
    • Organizer
      第36回日本眼科手術学会総会
    • Place of Presentation
      博多
    • Related Report
      2013 Final Research Report
  • [Presentation] Bioengineered Stroma Using a New Biocompatible Cross Linker.2013

    • Author(s)
      Soma T
    • Organizer
      TERMIS-AP
    • Place of Presentation
      Wuzhen, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Efficacy of a novel bioengineered corneal stroma fabricated by a new biocompatible cross linker in corneal stromal disease model.2013

    • Author(s)
      Soma T, Matsusaki M, Ajiro H, Tsujikawa M, Hayashi R, Oie Y, Akashi M, Nishida K
    • Organizer
      ARVO 2013
    • Place of Presentation
      Seattle, US
    • Related Report
      2013 Annual Research Report
  • [Presentation] Symposium : Bioengineered Stroma Using a New Biocompatible Cross Linker2012

    • Author(s)
      Soma T
    • Organizer
      3rd Asia Cornea Society Biennial Scientific Meeting
    • Place of Presentation
      Manila, Philippines
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium : New ocular therapeutic regimens; Amniotic Membrane Transplantation for Ocular Surface Reconstruction2012

    • Author(s)
      Soma T
    • Organizer
      The 27th Asia Pacific Academy of Ophthalmology Congress
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium : Challenging Cases symposium for the Cataract subspecialty; Cataract Surgery in Patients with Severe Corneal Opacity2012

    • Author(s)
      Soma T
    • Organizer
      The 27th Asia Pacific Academy of Ophthalmology Congress
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] 角膜移植後における角膜上皮厚と角膜知覚についての検討2012

    • Author(s)
      相馬剛至、三浦聡子、大家義則、中尾武史、高静花、辻川元一、前田直之、西田幸二
    • Organizer
      第66回日本臨床眼科学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体適合性架橋剤を用いた角膜実質再生治療法の開発2012

    • Author(s)
      相馬剛至、松崎典弥、網代広治、辻川元一、林竜平、大家義則、明石満、西田幸二
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] フェムトセカンドレーザーと生体適合性架橋剤を用いた角膜実質再生治療法の開発2012

    • Author(s)
      相馬剛至、松崎典弥、網代広治、辻川元一、林竜平、大家義則、明石満、西田幸二
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] コラーゲン選択的な生体適合性架橋剤とアテロコラーゲンによる人工角膜実質の開発2012

    • Author(s)
      相馬剛至、松崎典弥、網代広治、田中祐二、久保田享、明石満、西田幸二
    • Organizer
      角膜カンファランス2012
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 角膜内皮移植術(DSAEK)における新しい内皮グラフト挿入器の開発2011

    • Author(s)
      相馬剛至、大家義則、中尾武史、高静花、辻川元一、前田直之、西田幸二
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium : Retention and distribution of epithelial stem/progenitor cells following corneal reconstruction with tissue-engineered cell sheets using oral mucosal epithelial cells2011

    • Author(s)
      Soma T
    • Organizer
      Tianjin International Ophthalmology Forum 2011
    • Place of Presentation
      Tianjin, China
    • Year and Date
      2011-08-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium : Retention and Distribution of Epithelial Stem/Progenitor Cells following Corneal Reconstruction with Tissue-Engineered Cell Sheets using Oral Mucosal Epithelial Cells2011

    • Author(s)
      Soma T
    • Organizer
      Osaka University/ The Chinese University of Hong Kong Ophthalmology Forum 2011
    • Place of Presentation
      Osaka
    • Year and Date
      2011-08-04
    • Related Report
      2013 Final Research Report
  • [Presentation] TACSTD2の全身における発現および角膜における局在2011

    • Author(s)
      相馬剛至、辻川元一、林竜平、林田康隆、景山智文、原進、中尾武史、高静花、前田直之、西田幸二
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium : Histological evaluation of mechanical epithelial separation in epi-LASIK; Possibility of an alternative procedure to LASIK2011

    • Author(s)
      Soma T
    • Organizer
      The Sino-Japanese Ocular Surface Disease Research Collaboration Joint Meeting
    • Place of Presentation
      Xiamen, China
    • Year and Date
      2011-01-15
    • Related Report
      2013 Final Research Report
  • [Book] Diagnosticsスリットランプ上達講座スリットランプによる前眼部疾患の見方(解説) 眼科グラフィック2(2)2013

    • Author(s)
      相馬剛至
    • Related Report
      2013 Final Research Report
  • [Book] 角膜内皮移植/DSAEK用ドナーインジェクターについて教えてください 専門医のための眼科診療クオリファイ12 角膜内皮障害to the Rescue2012

    • Author(s)
      相馬剛至
    • Related Report
      2013 Final Research Report
  • [Book] 中央部の浮腫専門医のための眼科診療クオリファイ12 角膜内皮障害to the Rescue2012

    • Author(s)
      相馬剛至
    • Related Report
      2013 Final Research Report
  • [Book] 【眼科生体染色のアップデート】前眼部編角膜疾患の生体染色あたらしい眼科29(12)2012

    • Author(s)
      相馬剛至
    • Related Report
      2013 Final Research Report
  • [Book] 【円錐角膜の新たな治療】深層層状角膜移植眼科手術25(4)2012

    • Author(s)
      相馬剛至
    • Related Report
      2013 Final Research Report
  • [Book] 角膜内皮移植(DSAEK)DSAEKのドナー挿入法眼科手術24(4)2011

    • Author(s)
      相馬剛至、西田幸二
    • Related Report
      2013 Final Research Report
  • [Book] 角膜移植(眼球提供から移植まで)眼科53(12)2011

    • Author(s)
      相馬剛至
    • Related Report
      2013 Final Research Report
  • [Book] 培養上皮細胞シート移植(眼科最新手術) -- (角結膜)眼科53(10)2011

    • Author(s)
      相馬剛至、西田幸二
    • Related Report
      2013 Final Research Report
  • [Book] 第64回臨床眼科学会学会印象記.一般講演「角結膜手術」眼科532011

    • Author(s)
      相馬剛至
    • Related Report
      2013 Final Research Report
  • [Book] 学会トピックス角膜カンファランス2011培養上皮細胞シート移植後の上皮幹細胞・前駆細胞の保存と分布日眼1152011

    • Author(s)
      相馬剛至
    • Total Pages
      548
    • Related Report
      2013 Final Research Report
  • [Book] 海外文献紹介上皮幹細胞を用いた角膜再生医療とその長期成績再生医療102011

    • Author(s)
      相馬剛至、西田幸二
    • Total Pages
      80
    • Related Report
      2013 Final Research Report
  • [Book] Stevens-Johnson症候群、多形滲出性紅斑、天疱瘡/眼類天疱瘡 専門医のための眼科診療クオリファイ5 全身疾患と眼2010

    • Author(s)
      相馬剛至、西田幸二
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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