elucidation of the intrahepatic bile duct regenerative mechanism after Kasai procedure : a molecular biological approach

• Project/Area Number: 23792025
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatric surgery
• Research Institution: Tohoku University
• Principal Investigator: TANAKA HIROMU 東北大学, 大学病院, 助教 (50579448)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 胆道閉鎖症 / 胆管上皮細胞分化 / 胆管再生 / 胆管細胞 / 胆管

Outline of Final Research Achievements

We investigated the factor that make possible Jaundice free in comparison with age in days and, presence or absence of Jaundice after Kasai procedure using microarray analysis.The numbers of Tanscript Cluster which show more than double in comparison with presence or absence of Jaundice were 325.