Searching for new treatment of Hirschspurung disease by using newly developed mice model
| Project/Area Number |
23792033
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatric surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
TANAKA Nana 順天堂大学, 医学部, 助教 (50530656)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヒルシュスプルング病 / 神経堤細胞 / マウスモデル / 蛍光イメージング / 腸管神経系 / 細胞外マトリックス / ラミニン / 動物モデル / 仙骨神経堤細胞 / Sox10 / 器官培養 / 疾患モデルマウス / animal model / 神経提細胞 / ライブイメージング / SOX10 |
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| Research Abstract |
Disruption of vagal enteric neural crest cells(NCC) migration appears to induce sacral NCC activation in the anorectum, which could have implications for the etiology of the thick nerve fibers seen in Hirschsprung disease(HD) anorectum, which could in fact be a secondary phenomenon.
To establish new treatment for HD, we examined the effect of laminin-1 in NCC migration using SOX10-Venus mice gut. Our results suggest that laminin promotes NCC migration in mice.
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Report
(4 results)
Research Products
(18 results)
