To determine the intracellular signaling of keloid fibroblasts; especially the responses of purinoceptors
| Project/Area Number |
23792052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ATP / 肥厚性瘢痕 / ケロイド / 細胞内カルシウム濃度 / P2受容体 / 共焦点レーザー顕微鏡 |
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| Research Abstract |
The purpose of the research is to determine the difference between intracellular signaling of normal fibroblasts and keloid fibroblasts, with emphasis on the responses of adenosine triphosphate (ATP) and purinoceptors. Fibroblasts were isolated from keloid and normal skin tissue that were obtained from human skin. Each cell has the specific responses of extracellular ATP. Fluorescent staining showed that each cell has the specific arrangement of cytoskeleton (F-actin) and endoplasmic reticulum density.
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Report
(3 results)
Research Products
(9 results)
