Supramolecular ferric porphyrins and a cyclodextrin dimer as an antidote for cyanide poisoning.
| Project/Area Number |
23792089
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | シアン化合物 / 解毒剤 / イミダゾール・シクロデキストリン / 青酸化合物 / 超分子錯体 / シアン化合物中毒 |
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| Research Abstract |
The purpose of this study was to evaluate an imidazole cyclodextrin (FeIIIPIm3CD) which we have developed as an antidote for acute cyanide poisoning. Both in vitro study using murine fibroblast cell and in vivo study using mice, FeIIIPIm3CD demonstrated a significantantidotal effect against potassium cyanide, which was more effective than that of existing antidote (cobalt compounds).
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Report
(3 results)
Research Products
(13 results)
