Supramolecular ferric porphyrins and a cyclodextrin dimer as an antidote for cyanide poisoning.

• Project/Area Number: 23792089
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Tokai University
• Principal Investigator: YAMAGIWA Takeshi 東海大学, 医学部, 講師 (70439727)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: シアン化合物 / 解毒剤 / イミダゾール・シクロデキストリン / 青酸化合物 / 超分子錯体 / シアン化合物中毒

Research Abstract

The purpose of this study was to evaluate an imidazole cyclodextrin (FeIIIPIm3CD) which we have developed as an antidote for acute cyanide poisoning. Both in vitro study using murine fibroblast cell and in vivo study using mice, FeIIIPIm3CD demonstrated a significantantidotal effect against potassium cyanide, which was more effective than that of existing antidote (cobalt compounds).

Research Products

• [Journal Article] Supramolecular ferric porphyrins and a cyclodextrin dimer as an antidote for cyanide poisoning (2013)
  • Author(s): Yamagiwa T, Kawaguchi AT, Saito T, Inoue S, Morita S, Watanabe K, Kitagishi H, Kano K, Inokuchi S.
  • Journal Title: Human and Experimental Toxicology
  • Peer Reviewed
• [Presentation] 青酸に対するイミダゾール配位超分子鉄ポルフィリン(ImCD)の解毒効果;マウスin vivoにおける検討 (2012)
  • Author(s): 山際武志
  • Organizer: 第40回日本救急医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2012-11-15
• [Presentation] Imidazole cyclodextrin as a novel antidote for acute cyanide poisoning: Comparison with existing antidotes (2012)
  • Author(s): Yamagiwa T
  • Organizer: 16th International Society of Burn Injury (ISBI 2012).
  • Place of Presentation: Edinburgh(Scotland)
  • Year and Date: 2012-09-10
• [Presentation] 青酸に対するイミダゾール配位超分子鉄ポルフィリン(ImCD)の解毒効果 マウスin vivoにおける検討 (2012)
  • Author(s): 山際武志
  • Organizer: 第40回日本救急医学会総会
  • Place of Presentation: 京都
• [Presentation] Imidazole Cyclodextrin as a Novel Antidote for Acute Cyanide Poisoning: Comparison with Existing Antidotes (2012)
  • Author(s): Yamagiwa T.
  • Organizer: The 16th Congress of the International Society for Burn Injuries
  • Place of Presentation: Edinburgh
• [Presentation] 急性シアン化合物中毒に対する新たな全合成解毒剤"イミダゾール・シクロデキストリン"のin vitroにおける効果 (2011)
  • Author(s): 山際武志
  • Organizer: 第39回日本救急医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-19
• [Presentation] Imidazole cyclodextrin; totallysynthetic supramolecular complex as an antidote for cyanide poisoning (2011)
  • Author(s): Yamagiwa T
  • Organizer: 38th Congress of European Society of Artificial Organs
  • Place of Presentation: Porto (Portugal)
  • Year and Date: 2011-10-10
• [Presentation] Imidazole cyclodextrin as an antidote against cyanide poisoning, in vitro and in vivo study (2011)
  • Author(s): Yamagiwa T
  • Organizer: The International Association of Forensic Toxicology (TIAFT 2011).
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2011-09-30
• [Presentation] In vitroにおけるシアン化合物に対する解毒剤の評価方法の確立 (2011)
  • Author(s): 山際武志
  • Organizer: 第33回日本中毒学会総会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-07-31
• [Presentation] Imidazole Cyclodextrin (ImCD) as an Antidote for Cyanide Poisoning: In Vitro and In Vivo Results (2011)
  • Author(s): Takeshi Yamagiwa, Takeshi Saito, Akira T Kawaguchi, Kenji Watanabe, Hiroaki Kitagishi, Koji Kano, Sadaki Inokuchi.
  • Organizer: 2011 Joint meeting of the SOFT & TIAFT
  • Place of Presentation: Marriot Marquis Hotel, San Francisco, Calfornia, USA
• [Presentation] Imidazole Cyclodextrin (ImCD); Totally Synthetic Supramolecular Complex as an Antidote for Cyanide Poisoning (2011)
  • Author(s): Takeshi Yamagiwa, Akira T Kawaguchi, Takeshi Saito, Kazuo Umezawa, Hiroaki Kitagishi, Kenji Watanabe, Koji Kano, Sadaki Inokuchi.
  • Organizer: 4th Joint ESAO-IFAO Congress 2011
  • Place of Presentation: Porto Congress Centre, Porto, Portugal
• [Presentation] 急性シアン化合物中毒に対する新たな全合成解毒剤"イミダゾールシクロデキストリン"のin vitroにおける効果 (2011)
  • Author(s): 山際武志、斎藤剛、川口章、渡辺憲司、北岸宏亮、山本五十年、加納航治、猪口貞樹
  • Organizer: 第39回日本救急医学会総会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] In vitroにおけるシアン化合物に対する解毒剤の評価方法の確立 (2011)
  • Author(s): 山際武志、斎藤剛、川口章、城所正子、梅澤和夫、山本五十年、猪口貞樹
  • Organizer: 第33回日本中毒学会総会
  • Place of Presentation: ソフトピアジャパン、岐阜