| Project/Area Number |
23792092
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
|
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 重症熱傷 / ミトコンドリア / アラーミン / ミトコンドリアDNA / 外傷 / ISS / DAMPｓ / NETs / 敗血症 / DNA / アポトーシス |
|---|
| Research Abstract |
This study examined if mitochondrial DNA (mtDNA) is involved in severe systematic inflammatory response syndrome (SIRS) of severe traumatic patients. Blood mtDNA levels, inflammatory responses, and traumatic scores were examined. Patients with high ISS scores, showed elevated blood mtDNA after admission and remained high on day 5. Whereas, blood mtDNA levels in mild traumatic patients were similar to those of healthy individuals. Our results show that free mtDNA in serum may act as an inflammatory mediator.
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