| Project/Area Number |
23792109
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
SATO Keiko 長崎大学, 医歯薬学総合研究科, 助教 (70410579)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 歯周病 / 病原因子 / 細菌学 / プロテアーゼ / 細菌 / タンパク質分泌 |
|---|
| Research Abstract |
The gram-negative bacterium Porphyromonas gingivalis possesses a number of potential virulence factors for periodontopathogenicity. Particulary, cysteine proteases, named gingipains, are important virulence factors because of degradation of host proteins and responsibility for processing/maturation of P. gingivalis virulence factors. The PorSS is involved in the secretion of the proteins containing CTD that are essential for colony pigmentation, hemeagglutination, adherence, and virulence of bacterial pathogen of P. gingivalis.
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