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Characterization of myoblast differentiation and localization during early myogenesis in mouse tongue

Research Project

Project/Area Number 23792116
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

FUJITA Kazuya  日本歯科大学, 生命歯学部, 助教 (70549055)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords歯学 / マウス胎仔 / 舌初期発生 / 筋芽細胞分化 / マイクロアレイ / IPA 解析 / mRNA/miRNAマイクロアレイ / IPA解析 / 病理学 / 舌筋分化
Research Abstract

The present study aimed to characterize the molecular networks that govern tongue myogenesis in mouse embryos. The gene expression profiling by microarray analyses, together with quantitative PCR analysis and immunohistochemical validation, demonstrated that the expression of myogenesis-related genes were strongly up-regulated during early tongue morphogenesis (Embryonic days from 10.5 to 11.5). We also delineated concomitant expression of microRNAs that might interact with transcripts of regulatory genes for myoblast differentiation in tongue primordium.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (13 results) Remarks (3 results)

  • [Journal Article] Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family.2013

    • Author(s)
      Kazuya Fujita
    • Journal Title

      Int. J. Dev. Biol.

      Volume: 57 Issue: 5 Pages: 1-8

    • DOI

      10.1387/ijdb.120110ys

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ノンコーディングRNAによる遺伝子発現制御と病態―セロトニン受容体修飾と摂食障害2011

    • Author(s)
      添野雄一
    • Journal Title

      歯学

      Volume: 98 Pages: 185-188

    • Related Report
      2011 Research-status Report
  • [Presentation] マウス舌発生における舌筋前駆細胞の移住は舌下神経の軸索誘導に働く2012

    • Author(s)
      田谷雄二,島津徳人,佐藤かおり,藤田和也,添野雄一,青葉孝昭
    • Organizer
      第54回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      福島県
    • Year and Date
      2012-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Embryonic morphogenesis and organization of vascular and nervous networks in mouse craniofacial region2012

    • Author(s)
      Taya Y, Shimazu Y, Fujita K, Soeno Y,Sato K, Aoba T
    • Organizer
      Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      兵庫県
    • Year and Date
      2012-05-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Myoblast-differentiation and mRNA/miRNA expression in developmental mouse tongue2012

    • Author(s)
      Fujita K, Soeno Y, Taya Y, Shimazu Y, Sato K, and Aoba T
    • Organizer
      41stAnnual meeting & exhibition of theAmerican Assosiation for Dental Research
    • Place of Presentation
      Tampa, Florida, USA
    • Year and Date
      2012-03-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Myoblast-differentiation and mRNA/miRNA expression in developmental mouse tongue2012

    • Author(s)
      Fujita Kazuya
    • Organizer
      American Assosiation for Dental Research
    • Place of Presentation
      Tampa Convention Center(USA)
    • Related Report
      2011 Research-status Report
  • [Presentation] マウス舌初期発生と筋芽細胞分化の分子制御:miRNA・タンパク質の発現局在2011

    • Author(s)
      藤田和也,添野雄一,田谷雄二,島津徳人,佐藤かおり,青葉孝昭
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県
    • Year and Date
      2011-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス舌初期発生における筋芽細胞分化のタイミングと遺伝子発現制御2011

    • Author(s)
      藤田和也,田谷雄二,佐藤かおり,島津徳人,添野雄一,青葉孝昭
    • Organizer
      第53回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      岐阜県
    • Year and Date
      2011-10-02
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス舌初期発生における筋芽細胞分化のタイミングと遺伝子発現制御2011

    • Author(s)
      藤田和也
    • Organizer
      日本歯科基礎医学会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Related Report
      2011 Research-status Report
  • [Presentation] マウス舌初期発生と筋芽細胞分化の分子制御:miRNA・タンパク質の発現局在2011

    • Author(s)
      藤田和也
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] マウス顎顔面領域における器官発生の分子制御:下顎突起癒合期における脈管網・神経網の構築2011

    • Author(s)
      田谷雄二
    • Organizer
      日本歯科基礎医学会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Three-dimensional visualization of developing vascular-nervous networks in embryonic mice.

    • Author(s)
      Yuji Taya
    • Organizer
      2012 Sino-Japan Dental Conference
    • Place of Presentation
      四川大学(中国)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 癌微小環境におけるHIF-1α陽性核の空間分布と血管新生誘導.

    • Author(s)
      藤田和也
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Embryonic morphogenesis and organization of vascular and nervous networks in mouse craniofacial region.

    • Author(s)
      Yuji Taya
    • Organizer
      第64回日本細胞生物学会・第45回日本発生生物学会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス舌発生における舌筋前駆細胞の移住は舌下神経の軸索誘導に働く.

    • Author(s)
      田谷雄二
    • Organizer
      第54回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      奥羽大学(福島県)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.ndu.ac.jp/~pathhome/index/

    • Related Report
      2012 Final Research Report
  • [Remarks] 日本歯科大学病理学講座HP

    • URL

      http://www.ndu.ac.jp/~pathhome/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.ndu.ac.jp/~pathhome/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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