Analysis of residual Porphyromonas gingivalis biofilms in vitroaftertreatment with antibiotic
| Project/Area Number |
23792171
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | バイオフィルム / クロルヘキシジン / ポルフィロモナスジンジバリス |
|---|
| Research Abstract |
This study showed that chlorhexidine-gluconate disrupted individual biofilm-forming Porphyromonas gingivalis cells, which is a major pathogen in marginal periodontitis and refractory periapical periodontitis, but did not destroy the biofilms, and the constituents derived from disrupted cells were maintained in the biofilm.Moreover, it is suggested that proteins are the major contributors to the integrity of the residual biofilms.
|
Report
(3 results)
Research Products
(14 results)
