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Analysis of residual Porphyromonas gingivalis biofilms in vitroaftertreatment with antibiotic

Research Project

Project/Area Number 23792171
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

YAMAGUCHI Mikiyo  大阪大学, 歯学部附属病院, 医員 (30523089)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsバイオフィルム / クロルヘキシジン / ポルフィロモナスジンジバリス
Research Abstract

This study showed that chlorhexidine-gluconate disrupted individual biofilm-forming Porphyromonas gingivalis cells, which is a major pathogen in marginal periodontitis and refractory periapical periodontitis, but did not destroy the biofilms, and the constituents derived from disrupted cells were maintained in the biofilm.Moreover, it is suggested that proteins are the major contributors to the integrity of the residual biofilms.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Porphyromonas gingivalis biofilms persist after chlorhexidine treatment2013

    • Author(s)
      Mikiyo Yamaguchi, Yuichiro Noiri, Masae Kuboniwa, Reiko Yamamoto, Yoko Asahi, Hazuki Maezono, Mikako Hayashi, Shigeyuki Ebisu
    • Journal Title

      European Journal of Oral Sciences.

      Volume: 121 Pages: 162-168

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Porphyromonas gingivalis biofilms persist after chlorhexidine treatment2013

    • Author(s)
      Mikiyo Yamaguchi
    • Journal Title

      European Journal of Oral Sciences

      Volume: 未定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The sinR ortholog PGN_0088 encodes a transcriptional regulator that inhibits polysaccharide synthesis in Porphyromonas gingivalis ATCC 33277 biofilms.2013

    • Author(s)
      Reiko Yamamoto
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 根尖孔外バイオフィルムと根尖性歯周炎の難治化2012

    • Author(s)
      山口幹代, 野杁由一郎
    • Journal Title

      日本歯科評論

      Volume: 72 Pages: 41-50

    • Related Report
      2012 Final Research Report
  • [Journal Article] Porphyromonas gingivalisのバイオフィルムに対するクロルヘキシジンの影響2011

    • Author(s)
      山口幹代, 野杁由一郎, 久保庭雅恵, 山本れいこ, 前薗葉月, 朝日陽子, 呉本勝隆 , 恵比須繁之
    • Journal Title

      Bacterial Adherence & Biofilm

      Volume: 25 Pages: 53-58

    • Related Report
      2012 Final Research Report
  • [Journal Article] 根管治療を再考するーその成功と失敗の鍵ー2011

    • Author(s)
      野杁由一郎, 山口幹代, 林 美加子, 恵比須繁之
    • Journal Title

      日歯内療誌

      Volume: 32 Pages: 87-96

    • NAID

      10029089649

    • Related Report
      2012 Final Research Report
  • [Journal Article] Porphyromonas ginigvalisのバイオフィルムに対するクロルヘキシジンの影響2011

    • Author(s)
      山口幹代、野杁由一郎、久保庭雅恵、山本れいこ、前薗葉月、朝日陽子、呉本勝隆、恵比須繁之
    • Journal Title

      Bacterial Adherence & Biofilm

      Volume: Vol.25 Pages: 53-58

    • Related Report
      2011 Research-status Report
  • [Presentation] Porphyromonas gignivalis のバイオフィルム形成におけるプロテアーゼの役割.2012

    • Author(s)
      山口幹代
    • Organizer
      第136回日本歯科保存学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄)
    • Year and Date
      2012-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Remnant matrix of Porphyromonas gingivalis biofilms treated with chlorhexidine2011

    • Author(s)
      Yamaguchi Mikiyo
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2011-09-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Porphyromonas gingivalis のバイオフィルムに対するクロルヘキシジンの影響2011

    • Author(s)
      山口幹代
    • Organizer
      第25回 Bacterial Adherence & Biofilm 学術集会
    • Place of Presentation
      東京慈恵会医科大学 (東京)
    • Year and Date
      2011-07-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Porphyromonas ginigvalisのバイオフィルムに対するクロルヘキシジンの影響2011

    • Author(s)
      山口幹代、野杁由一郎、久保庭雅恵、山本れいこ、前薗葉月、朝日陽子、呉本勝隆、恵比須繁之
    • Organizer
      第25回Bacterial Adherence & Biofilm学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Dispersal of Porphyromonas gingivalis biofilm induced by environmental factors and proteases

    • Author(s)
      Mikiyo Yamaguchi
    • Organizer
      6th ASM Conference on Biofilms 2012
    • Place of Presentation
      マイアミ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Porphyromonas gingivalisのバイオフィルムの形成におけるプロテアーゼの役割

    • Author(s)
      山口幹代
    • Organizer
      日本歯科保存学会春季学術大会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Annual Research Report
  • [Book] 根尖病変 治癒に向けた戦略を究める2013

    • Author(s)
      山口幹代, 野杁由一郎
    • Publisher
      ヒョーロン・パブリッシャーズ
    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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