Elucidation of dental pulp cell differentiation by laser
| Project/Area Number |
23792197
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 細胞・組織 / 炎症 / レーザー / 再生医学 / シグナル伝達 |
|---|
| Research Abstract |
Dental pulp inflammation associated with the progression of dental caries facilitates the production of inflammatory cytokines, such as interleukin-1b (IL-1b), and enzymes, such as matrix metalloproteinases (MMPs), in the pulp tissue, resulting in tissue destruction. The results of this experiment suggest that MEK1/2 and ERK1/2 pathways were involved in the MMP-3 production enhanced by IL-1b stimulation in HPFs.
These samples consisted of 25 experimental group samples with 15 and 30-second, and 1, 3, and 5-minute irradiation times, and 0.5, 1, 2, 5, and 10-W irradiation outputs, and one control group sample without irradiation.However, for 0.5 - 10-W high-energy Semiconductor lasers, a decrease in the cell number due to cell death was observed after 3-minute irradiation, and no cell adhesion to the plate surface immediately after cell seeding was noted after 5-minute irradiation with the 10-W laser.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] The Effect of lysenin on the differentiation into osteoclast cells2011
Author(s)
Domae E, Ogawa Y, Takeuchi O, Ujii Y, Kato Y, Kawasaki T, Hayashi H, Komasa R, Domae N, Goda S, Ikeo T
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Journal Title
J Oral Tissue Engin
Volume: 9巻
Pages: 3-9
NAID
Related Report
Peer Reviewed
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[Presentation] 半導体レーザーが歯髄細胞に及ぼす影響について2012
Author(s)
吉川一志,竹内摂,田中芳人,鈴木康一郎,保尾謙三,廣田陽平,魯灵,畑下芳史,三木秀治,山本一世
Organizer
日本歯科保存学会2012年度秋季学術大会(第137回)
Place of Presentation
広島国際会議場(広島市)
Year and Date
2012-11-22
Related Report
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[Presentation] PDGF-bbはヒト歯肉由来線維芽細胞においてMMP-1産生を増強する2011
Author(s)
川崎俊也,合田征司,竹内摂,氏井庸介,林寛,小正玲子,加藤侑,林宏行,山本一世,池尾隆,松本尚之
Organizer
第9回日本再生歯科医学会学術大会・総会
Place of Presentation
大阪国際会議場(大阪市)
Year and Date
2011-09-10
Related Report
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