Bone regeneration of artificial bone adsorbed inorganic polyphosphate with long chain length

• Project/Area Number: 23792228
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthetic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: MORITA Koji 広島大学, 病院, 助教 (30555149)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ポリリン酸 / 骨再生 / 歯学 / 生体材料 / 再生医療

Research Abstract

These results in vitroa n d in vivomay indicate that inorganic polyphosphate with medium chain length of 65 accelerated bone regeneration compared to inorganic polyphosphate long chain length of 130. Within the limited results of this study, it may be concluded that artificial bone adsorbed inorganic polyphosphate with medium chain length of 65 and bFGF enhanced initial bone regeneration.

Research Products

• [Journal Article] The influence of fixation in formalin on the measurement of stability of implants using resonance frequency analysis and Periotest M[〇!R]: A study in a dog (2013)
  • Author(s): DOI:K,KajiharaS,MoritaK,MakiharaY,OkadaS,AkagawaY
  • Journal Title: Br J Oral Maxillofac Surg Volume: 13 Pages: 58-2
  • Peer Reviewed
• [Journal Article] Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway (2013)
  • Author(s): Sun N, Zou H, Yang L, Morita K, Gong P, Shiba T, Akagawa Y, Yuan Q
  • Journal Title: Biochem Biophys Res Commun Volume: 428 Pages: 298-302
  • Peer Reviewed
• [Journal Article] Development of Novel Implant/Interconnected Porous Calcium Hydroxyapatite Complex as New Concept Graft Material (2012)
  • Author(s): DOI:K,OueH,MoritaK,KajiharaS,KuboT,KoretakeK,PerrottiV,IezziG,PiattelliA,AkagawaY
  • Journal Title: PLOS ONE Volume: 7
  • Peer Reviewed
• [Journal Article] Influence of formalin fixation on implant stability quotient and bone mechanical characteristics (2012)
  • Author(s): Morita K, DOI: K, Oue H, Kajihara S, Hayashi K, Akagawa Y
  • Journal Title: Br J Oral Maxillofac Surg Volume: 12 Pages: 519-0
  • Peer Reviewed
• [Presentation] The influence of formalin fixation on implant stability quotient in an animal model (2012)
  • Author(s): Morita Koji
  • Organizer: The 8thCongress of the Asian Academy of Osseointegration(AAO)
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Influence of formalin fixation on implant stability quotient and bone mechanical characteristics (2012)
  • Author(s): Morita Koji
  • Organizer: European Association For Osseointegration(EAO)
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] Development of composite of poly(P) and bFGF with interconnected porous calcium hydroxyapatite (2012)
  • Author(s): Morita Koji
  • Organizer: 2012 Sino-Japan Dental Conference
  • Place of Presentation: Chengdu, China
• [Presentation] The Aspects of Osseointegration of The Implants Placed in The Reconstructed Bone by Using Interconnected Porous Calcium Hydroxyapatite (2011)
  • Author(s): KAJIHARA S, DOI K, OUE H, MATSUURA A, MORITA K, TAKESHITA R, ASAMORI C, AKAGAWA Y
  • Organizer: International College of Prosthodontists
  • Place of Presentation: Hawaii (USA)
• [Presentation] 連通多孔性ハイドロキシアパタイトを用いた骨再建部位におけるオッセオインテグレーションの様相 (2011)
  • Author(s): 梶原志穂, 土井一矢, 久保隆靖, 森田晃司, 赤川安正
  • Organizer: 日本口腔インプラント学会
  • Place of Presentation: 名古屋