Development of the evaluation method of mesenchymal stem cell'sosteogenic differentiation potential by gene analysis
| Project/Area Number |
23792237
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUEHIRO Fumio 長崎大学, 大学院・医歯薬学総合研究科, 助教 (40524781)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 間葉系幹細胞 / 転写因子 / 再生医療 / 顎骨骨髄由来細胞 / 歯槽骨増生 |
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| Research Abstract |
Human alveolar bone marrow derived stem cells had osteogenic and adipogenic differentiation potency, while did not almost have chondrogenic differentiation potency. In the previous study, we reported that ZHX3 might be used for prognostic marker for osteogenic potential of human iliac bone marrow derived stem cells;however, in this study, we noted that the levels of ZHX3 mRNA expression did not change at the initial stage of Human alveolar bone marrow derived stem cells osteogenic differentiation. The in vivo heterotopic bone formation model showed the result that was reverse to in vitro. The in vivo Human alveolar bone marrow derived stem cells bone formation potency may not necessarily accord with in vitro osteogenic differentiation potency.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Evaluation of trabecular bone formation in a canine model surrounding a dental implant fixture immobilized with an antimicrobial peptide derived from histatin2011
Author(s)
Makihira S, Nikawa H, Shuto T, Nishimura M, Mine Y, Tsuji K, Okamoto K, Sakai Y, Sakai M, Imari N, Iwata S, Takeda M, Suehiro F
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Journal Title
J Mater Sci Mater Med
Volume: 22(12)
Issue: 12
Pages: 2765-2772
DOI
NAID
Related Report
Peer Reviewed
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