| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
n the present study, we aimed to perform functional analysis of RIG-I using an oral carcinoma-derived cell line in order to clarify the signal transduction pathway of RIG-I, with the aim of regulating the cell cycle in oral cancer cells and stimulating immune system. In addition to RIG-I, DAI (DLM-1/ZBP1) and MDA-5 were analyzed with molecular biological method. Our data indicate RIG-I may have important roles in activation of caspase in apoptosis.
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