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Evaluation of bone regeneration using the hybrid materials of autogenous plasma and bone marrow mesenchimal stem cells

Research Project

Project/Area Number 23792324
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MARUKAWA Eriko  東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (40419263)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords自己血漿 / 幹細胞 / 骨再生 / 血漿 / fibrin / 骨髄間葉系幹細胞 / 骨髄穿刺液
Research Abstract

This study evaluated the effect of autogenous plasma and platelet-released growth factors to bone formation. PPP, PRP and PRF were implanted to each extraction socket in canine mandible. The amount of new bone formation was the highest in the PPP group, PPP and PRF could sufficiently maintain the bone width and height of the socket. β-TCP with bone marrow aspirate concentrate was implanted into the back muscle of dogs. This study indicated that BMAC comprises concentrated bone marrow stem cells and a fibrin scaffold that has the ability to induce ectopic bone formation

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2013 2012 2011

All Presentation (14 results)

  • [Presentation] Bone regeneration usinguncultured cells of bone marrow aspirate concentrate2013

    • Author(s)
      丸川恵理子
    • Organizer
      Osteology
    • Place of Presentation
      Monaco
    • Related Report
      2012 Final Research Report
  • [Presentation] The effects of autogenous plasma andplatelet-released growth factors in bone regeneration2013

    • Author(s)
      丸川恵理子
    • Organizer
      Osteology
    • Place of Presentation
      Monaco
    • Related Report
      2012 Final Research Report
  • [Presentation] Bone regeneration using uncultured cells of bone marrow aspirate concentrate2013

    • Author(s)
      丸川恵理子
    • Organizer
      Osteology
    • Place of Presentation
      monaco
    • Related Report
      2012 Annual Research Report
  • [Presentation] The effects of autogenous plasma and platelet-released growth factors in bone regeneration2013

    • Author(s)
      丸川恵理子
    • Organizer
      Osteology
    • Place of Presentation
      monaco
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨再生療法におけるplatelet-rich plasma(PRP)の効果2012

    • Author(s)
      丸川恵理子
    • Organizer
      第66回日本口腔科学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 濃縮非培養自己骨髄細胞とβ-TCPを用いた異所性骨誘導能の検討2012

    • Author(s)
      丸川恵理子
    • Organizer
      第11回日本再生医療学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Evaluation of boneregeneration induced by uncultured4×10 cells/ml接着細胞数bone marrow aspirate concentrate2012

    • Author(s)
      丸川恵理子
    • Organizer
      10th Asian Congress on Oral and Maxillofacial Surgery
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2012 Final Research Report
  • [Presentation] 幹細胞・フィブリン含有濃縮骨髄穿刺液を用いた骨誘導能の検討2012

    • Author(s)
      丸川恵理子
    • Organizer
      第57回日本口腔外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] PPP(platelet poor plasma),PRP(platelet rich plasma),PRF(platelet rich fibrin)を用いたイヌ抜歯窩歯槽堤保存における比較検討2012

    • Author(s)
      畠山一朗
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 骨再生療法におけるplatelet-rich plasma ( PRP ) の効果2012

    • Author(s)
      丸川恵理子
    • Organizer
      第66回日本口腔科学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Evaluation of bone regeneration induced by uncultured bone marrow aspirate concentrate2012

    • Author(s)
      丸川恵理子
    • Organizer
      10th Asian Congress on Oral and Maxillofacial Surgery
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2012 Annual Research Report
  • [Presentation] 自己フィブリンゲルの抜歯窩歯槽堤保存法への応用に関する実験的検討2011

    • Author(s)
      畠山一朗、 丸川恵理子、 高橋幸伸、 小村 健
    • Organizer
      第15回日本顎顔面インプラント学会総会・学術大会
    • Place of Presentation
      千葉市
    • Related Report
      2011 Research-status Report
  • [Presentation] イヌ抜歯窩での歯槽堤保存における乏血小板血漿(platelet poor plasma; PPP)と多血小板フィブリン(platelet rich fibrin; PRF)の効果2011

    • Author(s)
      畠山一朗、 丸川恵理子、 高橋幸伸、 小村 健
    • Organizer
      第3回多血小板血漿(PRP)療法研究会
    • Place of Presentation
      大阪市
    • Related Report
      2011 Research-status Report
  • [Presentation] 非培養自己骨髄細胞とβ-TCPを用いた骨再生療法への実験的検討.2011

    • Author(s)
      丸川恵理子、 高橋幸伸、 畠山一朗、 小村 健
    • Organizer
      第56回社団法人日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪市
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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