Study of Wnt signaling pathway for inhibition of invasion and Metastasis on oral squamous cell carcinoma.
| Project/Area Number |
23792339
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 口腔癌 / 浸潤 / 転移 / Wnt シグナル / beta-catenin / wntシグナル / Wntシグナル |
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| Research Abstract |
Aberrant cytoplasmic accumulation of beta-catenin can induce TCF/Lef-mediated transcriptional activity and enhance the migration of OSCC through the elevation of active Rho family, Cdc42 and Rac, and the rearrangement of actin filaments. Wnt5a may be involved in this enhancement of migration in OSCC , and be one of factors to link beta-catenin pathway with PCP pathway.
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Report
(3 results)
Research Products
(21 results)
