| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
We had developed the encapsulation of an i.v. formulation of midazolam which is bitter taste within liposomes and evaluated its pharmacokinetics on rabbits.
However the liposome-encapsulated midazolam had a problem that midazolam remained stably encapsulated by liposomes for only 1 week and were not fully satisfactory regarding overcoming the bitter taste. Thus the aim of the present study was to examine the way to remain stably for a long time and added sweetness to the liposome.
We start studying first step for the purpose of establishing the way of the freeze-drying as a long time stability. Trehalose and PEG which are reported increasing the stability of liposomes or freeze-drying liposomes were added to the liposome-encapsulated midazolam. As a result, the efficiency of liposomes to encapsulate midazolam containing 10% trehalose or 9% PEG were the highest and stably. Moreover, we studied the size reduction with the aim of increasing the efficiency of loposomes after freeze-drying.
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