Histological analysis of molecules participating in eating adjustment for the development period

• Project/Area Number: 23792405
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hokkaido University
• Principal Investigator: TAKASAKI Chihiro 北海道大学, 大学院・歯学研究科, 助教 (60451449)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 摂食 / マウス / 摂食調節 / 視床下部

Research Abstract

We analyzed molecules that adjust eating function in the wild-type mice brain. We found that cerebellin 1(Cbln1) mRNA, glutamate transporter VGluT2 mRNA and CB1 mRNA were coexpressed in the satiety center of the brain partly each. Therefore, it was suggested that Cbln1 and CB1 were distributed in the glutamatergic neuron, and participated in the adjustment of the eating function.