H2CO3 and PRP accelerates tooth movement

• Project/Area Number: 23792445
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Showa University
• Principal Investigator: SATO YUKI 昭和大学, 歯学部, 助教 (00384339)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 炭酸ガス

Research Abstract

PRP is blood plasma with concentrated platelets. H2CO3 is carbon dioxide. The purpose of this study was to clarify the effect of PRP on tooth movement of rat molar. (Methods) 11week rats. Ni-T closed coil (10g) placed and started tooth movement between U1 to M1 tooth. Rats assigned to the three group; 1-Control rats, 2-PRP rats 3-H2CO3. PRP (0.1ml/100g) or Physiological saline administered to palate when tooth movement starts. Rats fixed after 1, 3 and 7days of tooth movement. uCT taken and observed. The section stained by HE and TRAP, observed by light microscope (Results) PRP accelerated the tooth movement. Acceleration of the tooth movement will not show immediately after PRP administration. There is time difference. H2CO3 no found any significance difference up to 7days for tooth movement PRP accelerates tooth movement due to PRP transiently accelerating the entire alveolar bone resorbing activity but H2CO3 is not accelerating short term tooth movement.