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Is occlusion affected to a tooth-root during development?

Research Project

Project/Area Number 23792468
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

NAKASONE Naohiro  新潟大学, 医歯学総合病院, 医員 (20447634)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords咬合 / 歯根発生 / 歯根伸長 / 細胞増殖 / ラット / HERS / マイクロアレイ
Research Abstract

We analyzed whether occlusion is related to a tooth-root during root development in rat molars. First, we measured the width of cusps and root length using μ-CT. We demonstrated that the width of cusps in normal groups is significantly wider than that of experimental groups and the root length in normal groups is shorter than that in experimental groups. Furthermore, we elucidated that proliferating cells in root apex of normal groups is significantly less than that of experimental groups. These data have been accepted and published in European Journal of Oral Sciences.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (14 results)

  • [Journal Article] The change of HERS cell number and gene expression profile by occlusion during root development in rat molars2013

    • Author(s)
      Nakasone N, Ishida K, Yokoyama T, Okada M, Komatsu Y, Yoshie H
    • Journal Title

      Open Journal of Stomatology

      Volume: 3 Issue: 01 Pages: 8-14

    • DOI

      10.4236/ojst.2013.31002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Yttrium Aluminum Garnet (Er: YAG) Laser on Bacteremia due to Scaling and Root Planing2012

    • Author(s)
      Komatsu,Y, Morozumi T, Abe D, Okada M, Nakasone N, Okuda K, Yoshie H. Effects of Erbium-Doped
    • Journal Title

      J Lasers Med Sci

      Volume: 3 Pages: 175-184

    • Related Report
      2012 Final Research Report
  • [Journal Article] Occlusion regulates tooth-root elongation during root development in rat molars2011

    • Author(s)
      Nakasone N and Yoshie H
    • Journal Title

      Eur J Oral Sci

      Volume: 119 Pages: 418-426

    • Related Report
      2012 Final Research Report
  • [Journal Article] Occlusion regulates tooth-root elongation during root development in rat molars2011

    • Author(s)
      Nakasone N and Yoshie H
    • Journal Title

      European Journal of Oral Sciences

      Volume: VOL.119 Issue: 6 Pages: 418-426

    • DOI

      10.1111/j.1600-0722.2011.00856.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The change of HERS cell number and gene expression profile by occlusion during root development in rat molars

    • Author(s)
      Nakasone N, Ishida K, Yokoyama T, Okada M, Komatsu Y, Yoshie H
    • Journal Title

      Open J Stomatology

      Volume: (in press)

    • Related Report
      2012 Final Research Report
  • [Presentation] Amyloid beta (A4) precursor protein expression in periodontitis-affected gingival tissues2012

    • Author(s)
      Kubota T, Mauyama S, Abe D, Shimizu T, Nakasone N, Morozumi T, Saku T, Yoshie H
    • Organizer
      The 98th Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology (Research Forum Poster Session)
    • Place of Presentation
      Los Angeles, U.S.A
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular biological factors in drug-induced gingival overgrowth2012

    • Author(s)
      Shimizu T, Kubota T, Iwasaki M,Morozumi T, Nakasone N, Yoshie H
    • Organizer
      The98th Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology (Research Forum Poster Session)
    • Place of Presentation
      Los Angeles, U.S.A
    • Related Report
      2012 Final Research Report
  • [Presentation] Amyloid beta (A4) precursor protein expression in periodontitis-affected gingival tissues2012

    • Author(s)
      Kubota T, Maruyama D, Abe D, Shimizu T, Nakasone N, Morozumi T, Saku T, Yoshie H
    • Organizer
      EUROPERIO7 (Poster presentations)
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] Toll-like receptor (TLR) signaling pathway is upregulated in periodontitis-affected gingival tissues2012

    • Author(s)
      Abe D, Kubota T, Morozumi T, Nakasone N, Shimizu T, Yoshie H
    • Organizer
      EUROPERIO7 (Poster presentations)
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] Gene and proteinexpression of TNF-α converting enzyme(TACE/ADAM17) and tissue inhibitor of metalloproteinases (TIMP)-3 in gingival tissues from periodontitis patients with drug-induced gingival overgrowth2012

    • Author(s)
      Tomita T, Kubota T, Nakasone N, Iiyama M, Morozumi T, Nagata M, Horimizu M, Nono K, Yoshie H
    • Organizer
      EUROPERIO7
    • Place of Presentation
      Vienne, Austlia
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット臼歯歯根発生過程における、咬合によるヘルトヴィッヒの上皮鞘細胞数の変化2012

    • Author(s)
      中曽根直弘、石田光平、横山智子、岡田萌、小松康高、吉江弘正
    • Organizer
      第136回春季日本歯科保存学会
    • Place of Presentation
      宜野湾
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] TACE及びTIMP-3の炎症性歯肉組織中における遺伝子発現とタンパク質局在2011

    • Author(s)
      冨田尊志,久保田健彦,中曽根直弘飯山真奈美,両角俊哉,永田昌毅,堀水慎,濃野要,吉江弘正
    • Organizer
      第54回秋季日本歯周病学会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット臼歯歯根発生過程における咬合の影響2011

    • Author(s)
      中曽根直弘,吉江弘正
    • Organizer
      第54回春季日本歯周病学会,歯周病学会会誌
    • Place of Presentation
      博多
    • Year and Date
      2011-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Occlusion regulates tooth root elongation during root development in rat molars2011

    • Author(s)
      Nakasone N and Yoshie H
    • Organizer
      97th. American Academy of Periodontology Annual Meeting
    • Place of Presentation
      Miami Beach, Florida
    • Related Report
      2012 Final Research Report
  • [Presentation] Er:YAGレーザーによるSRP治癒効果および菌血症予防効果の検討2011

    • Author(s)
      小松康高,両角俊哉,小林哲夫,阿部大輔,岡田萌,奥田一博,中曽根直弘,吉江弘正
    • Organizer
      第135回秋季日本歯科保存学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット臼歯歯根発生過程における咬合の影響2011

    • Author(s)
      中曽根 直弘, 吉江 弘正
    • Organizer
      第54回春季日本歯周病学会学術大会
    • Place of Presentation
      博多
    • Related Report
      2011 Research-status Report
  • [Presentation] Occlusion regulates tooth-root elongation during root development in rat molars2011

    • Author(s)
      Naohiro Nakasone and Hiromasa Yoshie
    • Organizer
      97th American Academy of Periodontology Annual Meeting
    • Place of Presentation
      Miami Beach
    • Related Report
      2011 Research-status Report
  • [Presentation] TACE及びTIMP-3の炎症性歯肉組織中における遺伝子発現とタンパク質局在2011

    • Author(s)
      冨田 尊志, 久保田 健彦, 中曽根 直弘 飯山 真奈美, 両角 俊哉, 永田 昌毅, 堀水 慎, 濃野 要, 吉江 弘正
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      下関
    • Related Report
      2011 Research-status Report
  • [Presentation] Er: YAGレーザーによるSRP治癒効果および菌血症予防効果の検討2011

    • Author(s)
      小松 康高, 両角 俊哉, 小林 哲夫, 阿部 大輔, 岡田 萌, 奥田 一博, 中曽根 直弘, 吉江 弘正
    • Organizer
      第135回秋季日本歯科保存学会学術大会
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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