Effect for transcriptional activity by hypoxic condition on periodontal regeneration and inflammation
| Project/Area Number |
23792478
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 低酸素 / 間葉系幹細胞 / 歯周予防学 / 転写活性 / 再生歯学 / microRNA |
|---|
| Research Abstract |
In this study, it can be suggested that hypoxic condition can regulate MSCs cell function, mainly differentiation potential, by the interaction with hypoxia inducible factor (HIF)-1alpha and a group of transcription factors consisting of MSCs undifferentiating markers and micro RNA. Therefore, it can be expected that the regulation of hypoxia inducible transcription factors, especially by the control of local oxygen tension focused on the regulation of these gene expression, can result in “effective periodontal tissue regeneration with sustained homeostasis in periodontal tissue”.
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Report
(3 results)
Research Products
(3 results)
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[Presentation] Regulation of Osteogenesis in Mesenchymal Stem Cells by Periodontal Tissue2013
Author(s)
KANEDA, E., IWATA, T., FUJITA, T., ISHIDA, S., TAKAHASHI, K., SHIBA, H., and KURIHARA H.
Organizer
91st General Session & Exhibition of the International Association for Dental Research
Place of Presentation
Seattle, USA
Related Report
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