Effects of the Neutrophil Elastase on periodontal ligament cells and the clinical application of Neutrophil Elastase inhibitor to periodontal disease.
| Project/Area Number |
23792489
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
UJIIE Yuko 鶴見大学, 歯学部, 助教 (60588599)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯周予防学 / 好中球エラスターゼ / シベレスタット / 歯周病 / 歯根膜細胞 / 好中球エラスターゼ阻害剤 / 慢性歯周病疾患モデル / 破骨細胞 |
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| Research Abstract |
It is known that Neutrophil Elastase is one of the neutral proteinase and it degrade foreign objects at the inflammatory situation. The proteinase increased in the periodontal ligament which supports teeth, and it degraded non-collagenous matrix of periodontal ligaments. At this experiment, we demonstrated that the neutrophil elastase related with the degradation of periodontal ligament and bone matrix. Additionally, we implied a possibility that the inhibitor of neutrophil elastase restrained the differentiation of osteoclasts, moreover, the inhibitor suppressed a degradation of periodontal ligaments.
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Report
(3 results)
Research Products
(2 results)
