The analysis of inflammatory responses and effective care in chronic wounds
| Project/Area Number |
23792534
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Fundamental nursing
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
KANNO Emi 東北大学, 大学院・医学系研究科, 助教 (10431595)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 看護技術 / 創傷治癒 / 感染 / 炎症 / 免疫 / 創傷治癒学 / 慢性皮膚潰瘍 / 緑膿菌 / 難治性皮膚潰瘍 |
|---|
| Research Abstract |
Several bacteria, including Pseudomonas aeruginosa exist in chronic wounds with prolonged inflammatory reaction. In the present study, using a rat model with full-thickness dermal wounds, we examined the effect of P. aeruginosa and quorum sensing (QS) molecules, N-(3-oxododecanoyl)-_L-homoserine lactone (3-oxo-C_<12>-HSL), which is produced by P. aeruginosa. Within 3 days, inoculation with P. aeruginosa or3-oxo-C_<12>-HSL had accelerated local infiltration of neutrophils and tumor necrosis factor-α. These results indicate that 3-oxo-C_<12>-HSL may be involved in induction of inflammatory responses.
|
Report
(3 results)
Research Products
(21 results)
-
[Journal Article] Neutrophil-derived tumor necrosis factor-α contributes to acute wound healing promoted byN-(3-oxododecanoyl)-L-homoserine lactone from Pseudomonas aeruginosa2013
Author(s)
Emi Kanno, Kazuyoshi Kawakami, Shinichi Miyairi, Hiromasa Tanno, Hirono Otomaru, Arina Hatanaka, Shiori Sato, Keiko Ishii, Denso Hayashi, Nobuhito Shibuya, Yoshimichi Imai, Naomasa Gotoh, Ryoko Maruyama and Masahiro Tachi
-
Journal Title
Journal of Dermatological Science
Volume: 70
Pages: 130-138
URL
Related Report
Peer Reviewed
-
[Journal Article] Neutrophil-derived tumor necrosis factor-α contributes to acute wound healing promoted by N-(3-oxododecanoyl)-l-homoserine lactone from Pseudomonas aeruginosa.2013
Author(s)
Kanno, E., Kawakami, K, Miyairi, S., Tanno, H., Otomaru, H., Hatanaka, A., Sato, S., Ishii, K., Hayashi, D., Shibuya, N., Imai, Y., Gotoh, N., Maruyama, R., and Tachi, M.
-
Journal Title
J. Dermatol. Sci.
Volume: 70
Issue: 2
Pages: 130-138
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
