Analysis for endocannabinoid signaling in the epileptogenic circuit
| Project/Area Number |
23800001
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 内因性カンナビノイド / カンナビノイド受容体 CB1 / 歯状回 / てんかん / 神経科学 / 海馬 / シナプス |
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| Research Abstract |
This research project reveled the molecular anatomical basis fora major endocannabinoid, 2-arachidonoyl glycerol (2-AG), to effectively inhibit synaptic transmission at mossy cell-granule cell synapses, which constitute a potentiaepilectogenic circuit in the CNS. This suggests that 2-AG plays a role as a synapticcircuit breaker to prevent the epiletogenesis.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and indices neuritogenesis2012
Author(s)
Yaguchi, H., Okumura, F., Takahashi, H., Kano, T., Kameda, H., Uchigashima, M., Tanaka, S., Watanabe, M., Sasaki, H. and Hatakeyama, S.
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Journal Title
J. Biol. Chem.
Volume: 287
Issue: 15
Pages: 12050-12059
DOI
Related Report
Peer Reviewed
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