Exploring the mechanisms for adaptation to mechanical forces in theheart : Ca2+ handling and coronary microcirculation remodeling
| Project/Area Number |
23800067
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リモデリング / 心筋細胞 / 心肥大 / 心不全 / カルシウム / Na+/Ca2+交換体 / 機械的負荷 / 冠微小循環 / メカニカルストレス / 心機能 / Ca2+ハンドリング / 血行動態負荷 / カルシウム動態 / 冠循環 |
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| Research Abstract |
The cardiac Na+/Ca2+ exchanger is the predominant mechanism for the extrusion of Ca2+ from beating cardiomyocytes. To investigate the role of the Na+/Ca2+ exchanger during progression of heart failure, I generated pressure-overload-induced left ventricular hypertrophy and dysfunction. The Na+/Ca2+ exchanger activity decreased as the cardiac function failed, suggesting that a decrease in the extrusion of cytoplasmic Ca2+ may cause heart failure.
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Report
(3 results)
Research Products
(6 results)
