Exploring the mechanisms for adaptation to mechanical forces in theheart : Ca2+ handling and coronary microcirculation remodeling

• Project/Area Number: 23800067
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kawasaki Medical School
• Principal Investigator: UJIHARA Yoshihiro 川崎医科大学, 医学部, 助教 (80610021)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: リモデリング / 心筋細胞 / 心肥大 / 心不全 / カルシウム / Na+/Ca2+交換体 / 機械的負荷 / 冠微小循環 / メカニカルストレス / 心機能 / Ca2+ハンドリング / 血行動態負荷 / カルシウム動態 / 冠循環

Research Abstract

The cardiac Na+/Ca2+ exchanger is the predominant mechanism for the extrusion of Ca2+ from beating cardiomyocytes. To investigate the role of the Na+/Ca2+ exchanger during progression of heart failure, I generated pressure-overload-induced left ventricular hypertrophy and dysfunction. The Na+/Ca2+ exchanger activity decreased as the cardiac function failed, suggesting that a decrease in the extrusion of cytoplasmic Ca2+ may cause heart failure.

Research Products

• [Journal Article] Segmentation and morphometric analysis of cells from fluorescence microscopy images of cytoskeletons (2013)
  • Author(s): Yoshihiro Ujihara, Masanori Nakamura, Hiroshi Miyazaki, Shigeo Wada
  • Journal Title: Computational and Mathematical Methods in Medicine Volume: vol. 2013 Pages: 1-11
  • URL: http://dx.doi.org/10.1155/2013/381356
  • Peer Reviewed
• [Journal Article] Segmentation and morphometric analysis of cells from fluorescence microscopy images of cytoskeletons (2013)
  • Author(s): Yoshihiro Ujihara
  • Journal Title: Computational and Mathematical Methods in Medicine Volume: 2013 Pages: 1-11
  • DOI: 10.1155/2013/381356
  • Peer Reviewed
• [Journal Article] Contribution of actin filaments to the global compressive properties of fibroblasts (2012)
  • Author(s): Yoshihiro Ujihara, Masanori Nakamura, Hiroshi Miyazaki, Shigeo Wada
  • Journal Title: Journal of the Mechanical Behavior of Biomedical Materials Volume: vol.14 Pages: 192-198
  • DOI: 10.1016/j.jmbbm.2012.05.006
  • Peer Reviewed
• [Journal Article] Effects of Cytoskeletal Orientations on Deformation of a Cell Residing in a Collagen Gel Construct (2012)
  • Author(s): Masanori Nakamura, Yoshihiro Ujihara, Masatsugu Soga, Kenichiro Koshiyama, Hiroshi Miyazaki, Shigeo Wada
  • Journal Title: Journal of Biomechanical Science and Engineering Volume: 7 Issue: 1 Pages: 2-14
  • DOI: 10.1299/jbse.7.2
  • NAID: 130002066875
  • ISSN: 1880-9863
  • Peer Reviewed
• [Presentation] 発生段階の心筋細胞の分化・分裂機構の解明に向けた予備的解析 (2013)
  • Author(s): 橋本謙、氏原嘉洋、毛利聡
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京
• [Remarks]
  • URL: http://www.kawasaki-m.ac.jp/med/study/info.php?id=202