Roles of nuclear pore complex and lamina in intestinal tumor formation

Research Project

Project/Area Number	23800077
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Tumor biology
Research Institution	Aichi Cancer Center Research Institute
Principal Investigator	KOJIMA Yasushi 愛知県がんセンター(研究所), 分子病態学部, 主任研究員 (30464217)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	核膜孔複合体 / 核ラミナ / 大腸がん / 腫瘍生物学 / 大腸癌 / Wnt
Research Abstract	Recent reports have suggested that Nup88, a component of nuclear pore complex, and Lamin A, a major component of nuclear lamina are overexpressed during intestinal tumorigenesis. I analyzed functional relationships between Wnt signal pathway and expression of Nup88 and Lamin A/C. I found little evidence supporting roles of Wnt signaling in Nup 88 and Lamin A/C expression during intestinal tumorigenesis.