Roles of nuclear pore complex and lamina in intestinal tumor formation
Project/Area Number |
23800077
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Tumor biology
|
Research Institution | Aichi Cancer Center Research Institute |
Principal Investigator |
KOJIMA Yasushi 愛知県がんセンター(研究所), 分子病態学部, 主任研究員 (30464217)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 核膜孔複合体 / 核ラミナ / 大腸がん / 腫瘍生物学 / 大腸癌 / Wnt |
Research Abstract |
Recent reports have suggested that Nup88, a component of nuclear pore complex, and Lamin A, a major component of nuclear lamina are overexpressed during intestinal tumorigenesis. I analyzed functional relationships between Wnt signal pathway and expression of Nup88 and Lamin A/C. I found little evidence supporting roles of Wnt signaling in Nup 88 and Lamin A/C expression during intestinal tumorigenesis.
|
Report
(3 results)
Research Products
(2 results)