Risk-assessment of toxic components derived from biodiesel feedstockJatropha curcas.

Research Project

Project/Area Number	23880028
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Boundary agriculture
Research Institution	Kurume University
Principal Investigator	MOTOYUKI Nakao 久留米大学, 医学部, 助教 (60610566)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	バイオディーゼル / ジャトロファ / 発癌プロモーター / 健康影響評価 / 急性毒性 / ホルボールエステル / 環境分析 / 環境技術 / バイオ燃料 / リスク評価
Research Abstract	Jatropha curcas, one of the biodiesel feedstock has been drawing spotlight as uncompetitive biological resources with edible plant because it is unfit for human consumption due to its toxic components. In this study, risk assessment of the phorbol ester (PE) isolated from Jatropha was carried out. High concentration of Jatropha PE showed severe acute toxicity in applied mice. Jatropha PE showed strong tumor promotion activity in transformation assay using cultured cells. However, lower concentration of PE did not develop any tumor in mice. These results suggested that Jatropha PE differentially behaved in vivo and in vitro.