| Project/Area Number |
23890001
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
|---|
Principal Investigator |
OHNO Yusuke 北海道大学, 大学院・薬学研究院, 助教 (50611498)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 極長鎖脂肪酸 / 3-ヒロキシアシルCoA脱水酵素 / ミオパチー / 筋分化 / HACD / 3-ヒドロキシアシルCoA脱水酵素 / 不整脈源性右室異形成 |
|---|
| Research Abstract |
HACD1 is a protein engaged in elongation of very long-chain fatty acids, and is specifically expressed in heart and skeletal muscle. In this study, we demonstrated that HACD1 is involved in elongation of saturated fatty acids, whose carbon chain lengths are 16 to 26. We created Hacd1 knockout mice, and decreases in weight, muscle mass, and locomotor activity were observed in Hacd1 knockout mice.
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