| Project/Area Number |
23890003
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
KAJITA Mihoko 北海道大学, 遺伝子病制御研究所, 助教 (00607442)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 癌 / 上皮細胞 / Src / vimentin / filamin / filamin A / zebrafish |
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| Research Abstract |
At the initial stage of carcinogenesis, transformation occurs in single cells within epithelia. Recent studies have shown that certain types of transformed cells are extruded from an epithelial monolayer. However, molecular mechanisms are not clearly understood. In this project, using a biochemical screening, I have found that filamin A and vimentin are specifically modulated when normal and transformed epithelial cells interact with each other. I have also found that normal epithelial cells actively eliminate neighboring transformed cells via filamin A and vimentin.
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