Genome-wide association study for abnormal cranio-facial morphology

• Project/Area Number: 23890011
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hokkaido University
• Principal Investigator: SAITO Fumio 北海道大学, 北海道大学病院, 医員 (00612889)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 歯学 / ゲノム / 形態異常

Research Abstract

Two loci (1q32.2 and 1p22.3) were likely to be as novel susceptibility regions of mandibular prognathism.PLXNA2 and SSX2IP genes were considered as a genetic candidate.PLXNA2 gene is a gene encoding semaphorin co-receptors, and the relations to bone metabolism are reported in semaphorin 3A.SSX2IP gene is related to a Synovium Sarcoma and the temporomandibular joint that is related to mandibular growth has synovial tissue. We speculate that these genes may be also associated with mandibular prognathism.

Research Products

• [Journal Article] Histological study of the nasal septal cartilage in BALB/c-bm/bm mouse which spontaneously induces malocclusion (2012)
  • Author(s): Takahashi K, Kajii TS, Tsukamoto Y, Saito F, Wada S, Sugawara-Kato Y, Iida J.
  • Journal Title: Orthodontics & craniofacial research Volume: 15(2) Issue: 2 Pages: 84-91
  • DOI: 10.1111/j.1601-6343.2011.01538.x
  • Peer Reviewed
• [Journal Article] Morphological evaluation of cranial and maxillary shape differences of the brachymorphic mouse with spontaneous malocclusion using three-dimensional micro-computed tomography (2011)
  • Author(s): F Saito, et al.
  • Journal Title: Orthodontics & Craniofacial Research Volume: Volume 14, Issue 2 Issue: 2 Pages: 100-106
  • DOI: 10.1111/j.1601-6343.2011.01513.x
  • Peer Reviewed
• [Presentation] 下顎前突症(mandibular prognathism)のゲノムワイド 関連解析 (2012)
  • Author(s): 生野啓一郎、梶井貴史、岡晃、斉藤文男、猪子英俊、石川博之、飯田順一郎
  • Organizer: 日本人類遺伝学会第57回大会
  • Place of Presentation: 京王プラザホ テル(東京都)
• [Presentation] 下顎前突症（mandibular prognathism）のゲノムワイド関連解析 (2012)
  • Author(s): 生野啓一郎
  • Organizer: 日本人類遺伝学会第57 回大会
  • Place of Presentation: 京王プラザホテル（東京都）