Alteration of snRNAs in amyotrophic lateral sclerosis
| Project/Area Number |
23890060
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ALS / snRNA / U12 snRNA / スプライシング / 逆転写定量PCR / ｓｎRNA / U12 / 内在性コントロール |
|---|
| Research Abstract |
We stated and investigated the hypothesis that the dysfunction of TDP-43 causesreduction of snRNAs in amyotrophic lateral sclerosis (ALS). We revealed thedownregulation of U12 snRNA in the tissues affected with ALS and not in non-affectedtissues. Several U12-type intron splicing tended to be downregulated in ALS affectedtissues and culture cells with depleted TDP-43.
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Report
(3 results)
Research Products
(9 results)
