Gene and protein location of Tumour Necrosis Factor(TNF)- αconvertingenzyme in gingival tissues from periodontitis with drug-induced gingival overgrowth.

• Project/Area Number: 23890062
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: ABE Daisuke 新潟大学, 医歯学総合病院, 医員 (30609110)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: カルシウム拮抗薬剤性歯肉増殖症 / TACE / TIMP-3 / タンパク質発現解析 / 遺伝子発現解析 / 免疫組織化学 / ｑRTーPCR解析 / 免疫組織学的解析 / 医療・福祉 / 歯学 / 歯周病学 / 分子生物学 / 酵素

Research Abstract

The aim of the present study was to analyse mRNA expression of TACE and TIMP-3, and protein location of TACE in gingival tissue removed from drug-(calcium-channel blocker) induced GO and periodontitis.

Research Products

• [Journal Article] Gene and protein location of Tumour Necrosis Factor(TNF)- αconverting enzyme in gingival tissues from periodontitis with drug-induced gingival overgrowth
  • Author(s): Takayuki Tomita, Takehiko Kubota, Naohiro Nakasone, Toshiya Morozumi, Daisuke Abe, Satoshi Maruyama, Taro Shimizu, Makoto Horimizu, Takashi Saku and Hiromasa Yoshie
  • Journal Title: Archives of Oral Biology Volume: (in press)
  • Peer Reviewed
• [Presentation] Gene and protein location of Tumour Necrosis Factor(TNF)- α converting enzyme in gingival tissues from periodontitis with drug-induced gingival overgrowth (2012)
  • Author(s): Takayuki Tomita, Takehiko Kubota, Naohiro Nakasone, Toshiya Morozumi, Daisuke Abe, Satoshi Maruyama, Taro Shimizu, Makoto Horimizu, Takashi Saku and Hiromasa Yoshie
  • Organizer: EUROPERIO7
  • Place of Presentation: Messe Wien Exhibition & Conference Center(ウィーン)
• [Presentation] Gene and protein localisation of tumour necrosis factor (TNF)-α converting enzyme in gingival tissues from periodontitis patients with drug-induced gingival overgrowth. (2012)
  • Author(s): Takayuki Tomita
  • Organizer: EUROPERIO7
  • Place of Presentation: Messe Wien Exhibition & Conference Center