Myeloid derived suppressor cell(MDSC)-targeted immunotherapy for oral cancer

• Project/Area Number: 23890069
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: University of Toyama
• Principal Investigator: TOMIHARA Kei 富山大学, 大学病院, 医員 (70404738)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口腔癌 / マウスモデル / ミエロイド系抑制性細胞

Research Abstract

In a mouse model of oral cancer, accumulation of myeloid derived suppressor cells（MDSC) was observed in the tumor tissue, and this attenuation of MDSC was ameliorated by low dose gemcitabine administration.

Research Products

• [Journal Article] Aging-associated B7-DC(+) B cells enhance anti-tumor immunity via Th1 and Th17 induction (2012)
  • Author(s): Tomihara K, Shin T, Hurez VJ, Yagita H, Pardoll DM, Zhang B, Curiel TJ, Shin T
  • Journal Title: Aging Cell Volume: 11 Issue: 1 Pages: 128-138
  • DOI: 10.1111/j.1474-9726.2011.00764.x
  • Peer Reviewed
• [Presentation] Characterization of regulatory T cells (Tregs) in oral cancer (2012)
  • Author(s): Tomihara K, Inoue S, Takei R, Imaue S, Arai N, Noguchi M
  • Organizer: 10^<th>Asian congress on oral and maxillofacialsurgery
  • Place of Presentation: Bali Indonesia
• [Presentation] マウス口腔癌モデルを用いた制御性T細胞の解析 (2012)
  • Author(s): 冨原 圭、井上さやか、武井理恵、今上修一、新井直也、野口 誠
  • Organizer: 第30回 日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: 埼玉
• [Presentation] マウスモデルを用いた口腔癌における制御性T細胞の解析 (2012)
  • Author(s): 冨原 圭、井上 さやか、能登善弘、津野宏彰、立浪秀剛、新井直也、野口 誠
  • Organizer: 第66回 日本口腔科学会学術集会
  • Place of Presentation: 広島
• [Presentation] Regulatory T cells in oral cancer (2012)
  • Author(s): Tomihara K, Inoue S, Arai N, Noguchi M.
  • Organizer: 71^<th>Annual Meeting of the Japanese Cancer Association,第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 口腔癌における制御性T細胞の解析 (2012)
  • Author(s): 冨原 圭、井上 さやか、新井直也、野口 誠
  • Organizer: 第57回 日本口腔外科学会総会・学術大会
  • Place of Presentation: 横浜
• [Presentation] Analysis of the characterization of regulatory T cells in a mouse model for oral cancer (2011)
  • Author(s): Tomihara Kei, et al.
  • Organizer: 70^<th> Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 愛知県名古屋市