Investigation of the angiogenesis role by BMP2 and development of new method of osteogenesis by BMP2 producing cells

• Project/Area Number: 23890071
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Kanazawa University
• Principal Investigator: MATSUBARA Hidenori 金沢大学, 医学系, 医学系 (10507057)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: BMP2 / 血管内皮細胞 / LacZマウス / 骨延長 / 血管新生 / 創外固定

Research Abstract

We firstly showed that vascular endothelial cells and vascular smooth muscle cells produce BMP2 during distraction osteogenesis. During distraction osteogenesis, angiogenesis occurs at soft tissues around bone at first, which cells produce BMP2.It could promote bone regeneration. And it is showed that BMP2 from vascular cells and PIGF from soft tissue play an important role in bone formation.

Research Products

• [Journal Article] Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis (2012)
  • Author(s): Matsubara H, Hogan DE, Morgan EF, Mortlock DP, Einhorn TA, Gerstenfeld LC
  • Volume: 51
  • Pages: 1168-180
  • Peer Reviewed
• [Journal Article] Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis. (2012)
  • Author(s): Hidenori Matsubara
  • Journal Title: Bone Volume: 51(1) Issue: 1 Pages: 168-180
  • DOI: 10.1016/j.bone.2012.02.017
  • Peer Reviewed
• [Presentation] マウス大腿骨骨延長モデルにおけるMicro CTを用いた血管・骨描出法 (2012)
  • Author(s): 松原秀憲
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-10-27
• [Presentation] 骨延長術における血管内皮細胞・血管平滑筋細胞によるBMP2の産生 (2012)
  • Author(s): 松原秀憲
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-10-27
• [Presentation] マウス大腿骨骨延長モデルにおけるMicro CTを用いた血管・骨描出法 (2012)
  • Author(s): 松原秀憲
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 愛知県名古屋市 名古屋国際会議場
• [Presentation] 骨延長術における血管内皮細胞・血管平滑筋細胞によるBMP2の産生 (2012)
  • Author(s): 松原秀憲
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 愛知県名古屋市 名古屋国際会議場