Analysis of the host factor which is important for ovarian cancer dissemination

• Project/Area Number: 23890100
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: HASHIMOTO Kae 大阪大学, 医学系研究科, 助教 (90612078)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 卵巣癌 / 腹膜播種 / SDF-1

Research Abstract

This study was focused on the effect of SDF-1 on the ovarian cancer peritoneal dissemination. Stromal cell derived factor-1 (SDF-1) increased in the ascites of ovarian cancer model mice. SDF-1 promoted adhesion and invasion of ovarian cancer cell lines in vitro. Immunostaining showed SDF-1 was secreted from vascular pericytes or fibroblasts and tumor of TOV21G cell line. SDF-1 neutralizing antibody delayed tumor growth of advanced ovarian cancer model mice and prolonged survival.

Research Products

• [Journal Article] Low-dose metronomic oral dosing of a prodrug of Gemcitabine (LY2334737) causes anti-tumor effects in the absence of inhibition of systemic vasculogenesis. (2012)
  • Author(s): Francia G, Shaked Y, Hashimoto K, Sun J, Yin M, Cesta C, Xu P, Man S, Hackl C, Stewart J, Uhlik M, Dantzig A. H, Foster S, Kerbel R. S.
  • Journal Title: Mol Cancer Ther Volume: 11 Pages: 680-689
• [Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討 (2012)
  • Author(s): 久松武志, 馬淵誠士, 河野まひる, 橋本香映, 磯部晶, 澤田健二郎, 木村正
  • Organizer: 第52回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-19
• [Presentation] 上皮性卵巣癌における mTOR complex 2 (mTORC2) の発現とその臨床的意義の検討 (2012)
  • Author(s): 久松武志, 馬淵誠士, 河野まひる, 橋本香映, 磯部晶, 澤田健二郎, 木村正
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 兵庫
  • Year and Date: 2012-04-14
• [Presentation] 卵巣癌組織における Integrin α5 の発現が予後に与える影響の解析 (2012)
  • Author(s): 大八木知史, 澤田健二郎, 木瀬康人, 橋本香映, 馬淵誠士, 上浦祥司, 木村正
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 兵庫
  • Year and Date: 2012-04-14
• [Presentation] 卵巣癌癌性腹膜炎モデルにおける新規低分子 IKK 阻害剤(IMD-0540)の有効性の検討 (2012)
  • Author(s): 橋本香映, 澤田健二郎, 磯部晶, 大八木知史, 木瀬康人, 馬淵誠士, 木村正
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 兵庫
  • Year and Date: 2012-04-14
• [Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討 (2012)
  • Author(s): 久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 兵庫