Analysis of the effect of oxidative stress on abnormal placentation
| Project/Area Number |
23890101
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
MIMURA Kazuya 大阪大学, 医学系研究科, 助教 (50437422)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 胎盤形成 / 前置胎盤 / 酸化ストレス / チオレドキシン |
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| Research Abstract |
We assesed the expression of trophoblast invasion related molecules in placenta previa, especially accreta. We immunohistochemically assessed the expressions of thioredoxin (TRX), TLR3, TLR4, CD56, CD68, VEGF in the placenta of control, PIH, placenta previa and placenta accreta, and placental bed of control and placenta accreta. TRX expression is slightly higher in PIH placenta, especially chorion and decidua. In placenta previa and accreta, TRX expression is hardly seen in all the area of placenta.There are little differences of expression in other molecules. TRX expression decreased in placenta previa and accreta. It may indicate that oxidative stress decreases andtherefore preeclampsia frequency is reduced in placenta previa.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Imbalance of angiogenic factors and avascular edematous cystic villi in a trisomy 13 pregnancy: a case report2013
Author(s)
Kakigano, A. Mimura, K. Kanagawa, T. Nakayama, M. Kanayama, T. Fujita, S. Kinugasa-Taniguchi, Y. Endo, M. Tomimatsu, T. Kimura, T.
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Journal Title
Placenta
Volume: 34
Issue: 7
Pages: 628-630
DOI
Related Report
Peer Reviewed
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[Journal Article] Hypoxic preconditioning increases triiodothyronine (T3) level in the developing rat brain.2013
Author(s)
Minato K, Tomimatsu T, Mimura K, Jugder O, Kakigano A, Kanayama T, Fujita S, Taniguchi Y, Kanagawa T, Endo M, Kimura T.
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Journal Title
Brain Res
Volume: 1501
Pages: 89-97
DOI
Related Report
Peer Reviewed
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