Regulation of autoimmunity in NODRhebmice that represent increase of mTOR-dependent pancreatic βーcells and acceleration of autoimmune destruction.
| Project/Area Number |
23890114
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 1型糖尿病 / インクレチン / CFA / 妊娠 / NODRhebマウス / NOD^<Rheb>マウス / 膵β細胞量 |
|---|
| Research Abstract |
Administration of incretin (human GLP-1 analog) with or withoutCFA improved diabetes in newly diabetic NOD mice, but not in newly diabetic NODRhebmice (R3 lines), which accelerate diabetes progression. Newly diabetic NODRhebmice represented no induction of Treg into pancreatic islets and no islet regeneration. In addition, NODRhebmice showed more increased diabetes onset than NOD mice during the perinatal period and more decreased delivery. NODRhebmice also showed more accelerated diabetes progression than NOD mice after delivery.
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Report
(3 results)
Research Products
(16 results)
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[Presentation] 1 型糖尿病発症におけるMSR-A の役割の検討.2011
Author(s)
清水まみ, 安田尚史, 森山啓明, 中村 晃, 勝田敦美, 花野智苗, 佐々木弘智, 荒井隆志, 永田正男, 原 賢太, 横野浩一
Organizer
第9回 1 型糖尿病研究会.
Place of Presentation
大磯
Year and Date
2011-10-30
Related Report
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[Presentation] 膵β細胞 mTORC1 経路活性化による NOD マウス糖尿病発症に対する影響.2010
Author(s)
佐々木弘智, 森山啓明, 清水まみ, 中村 晃, 荒井隆志, 来住 稔, 濱田水鈴, 奥町恭代, 安田尚史, 原 賢太, 永田正男, 横野浩一
Organizer
第53回日本糖尿病学会総会.
Place of Presentation
岡山.
Year and Date
2010-05-29
Related Report
