Expression of PRL-3 and its clinicopathologic significance in oral squamous cell carcinoma

Research Project

Project/Area Number	23890125
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Okayama University
Principal Investigator	YOSHIDA Shoko 岡山大学, 岡山大学病院, 医員 (00616047)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	PRL-3 / 口腔扁平上皮癌
Research Abstract	Protein phosphatase of regenerating liver-3 (PRL-3) expressions were significantly higher in oral squamous cell carcinoma and oral epithelial dysplasia than in normal mucosa. PRL-3 expression were correlated with histological differentiation and histological grading of mode of invasion. PRL-3 expression was increased in squamous cell carcinoma and epithelial dysplasia in rat tongue carcinogenesis by 4-nitroquinoline 1-oxide. Our results suggest that PRL-3 plays a key role in tumorigenesis and it may be a novel marker of oral cancer progression.

Report

(3 results)