| Project/Area Number |
23890143
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
KURODA Shingo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (40332796)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | ナノ加工 / 骨治癒 / 遺伝子発現 / マイクロアレイ / チタン / インプラント |
|---|
| Research Abstract |
Untreated and H2SO4/H2O2-treated machined-surface titanium alloy implants were placed in rat tibiae. Samples were processed for DNA microarray analysis and histomorphometry. At both 3 and 5 days, the gene expression profile of the healing tissue around nanotextured implants differed from that around machined surface ones or control empty holes, and on day 5 were accompanied by increase in bone-implant contact. While some standard pathways, such as the immune response, predominated a number of unclassified genes were also implicated. In conclusion, nanotexture elicits an initial gene response that is more complex than so far suspected and that favors healing at the bone-implant interface.
|
