| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
We are intended to develop the gene therapy for neuromusculardisease, especially about amyotrophic lateralsclerosis. At the beginning, We consideredto use NB2a cells, origined from neuroblastoma, previously we have used, but we succeededto establish induced Pluripotent Stem (iPS) cells derived from amyotrophiclateralsclerosis patient skins, and these are considered to reflect pathology much morethan NB2a cells. Therefore, we started using these cells, and were continuing experimentsto prove the participation of endoplasmic reticulum stress. However, maintenancecultivation of an iPS cells is difficult from some technical problems, so we are seekingand solving these problems. If we resolve these problems, we expect that many resultsare obtained.
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