Gene therapy for neuromuscular disease
Project/Area Number |
23890163
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Neurology
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Research Institution | Kumamoto University |
Principal Investigator |
MORI Akira 熊本大学, 医学部附属病院, 医員 (70608877)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | 筋萎縮性側索硬化症 / 小胞体ストレス / Derlin-1 / 変異 SOD1 / 神経細胞死 / アデノ随伴ウイルス / induced Pluripotent Stem (iPS) 細胞 / iPS細胞 / 運動ニューロン / 小胞体関連分野 / 変異SOD1 / 遺伝子治療 / NB2a細胞 |
Research Abstract |
We are intended to develop the gene therapy for neuromusculardisease, especially about amyotrophic lateralsclerosis. At the beginning, We consideredto use NB2a cells, origined from neuroblastoma, previously we have used, but we succeededto establish induced Pluripotent Stem (iPS) cells derived from amyotrophiclateralsclerosis patient skins, and these are considered to reflect pathology much morethan NB2a cells. Therefore, we started using these cells, and were continuing experimentsto prove the participation of endoplasmic reticulum stress. However, maintenancecultivation of an iPS cells is difficult from some technical problems, so we are seekingand solving these problems. If we resolve these problems, we expect that many resultsare obtained.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Muscle biopsy findings predictive of malignancy in rare infiltrative dermatomyositis2013
Author(s)
Uchino M, Yamashita S, Uchino K, Mori A, Hara A, Suga T, Hirahara T, Koide T, Kimura E, Yamashita T, Ueda A, Kurisaki R, Suzuki J, Honda S, Maeda Y, Hirano T, Ando Y
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Journal Title
Clin Neurol Neurosurg
Volume: 115(5)
Issue: 5
Pages: 603-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Muscle biopsy findings predictive ofmalignancy in rare infiltrativedermatomyositis.2012
Author(s)
Makoto Uchino, Satoshi Yamashita, Katshhisa Uchino, Akira Mori, Akio Hara, Tomohiro Suga, Tomoo Hirahara, Tatsuya Koide, En Kimura, Taro Yamashita, Akihiko Ueda, Reiichi Kurisaki, Junko SuzukiShoji Honda, Yasushi Maeda, Teruyuki Hirano, Yukio Ando. Clin Neurol Neurosurg
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Journal Title
Clin Neurol Neurosurg
Volume: 115
Pages: 603-606
Related Report
Peer Reviewed
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[Journal Article] Derlin-1 overexpression amelioratesmutant SOD1-induced endoplasmic reticulumstress by reducing mutant SOD1accumulation.2011
Author(s)
Akira Mori, SatoshiYamashita, Katsuhisa Uchino, TomohiroSuga, Tokunori Ikeda, Koutaro Takamatsu,Masatoshi Ishizaki, Tatsuya Koide, EnKimura, Shuji Mita, Yasushi Maeda,Teruyuki Hirano and Makoto Uchino.
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Journal Title
Neurochemistry International
Volume: 58(3)
Pages: 344-53
Related Report
Peer Reviewed
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[Presentation] Significant CMAP decrement by repetitive nerve stimulation is more frequent in median than ulnar nerves of patients with amyotrophic lateral sclerosis.2012
Author(s)
1. Mori A, Yamashita S, Sakaguchi H, Kimura E, Maeda Y, Hirano T, Uchino M, Ando Y.
Organizer
23th international Symposium on ALS/MND,
Place of Presentation
Chicago, IL, USA
Related Report
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