The liver damage preventive effect of the new composition fat emulsion preparations in the long-term intravenous nutrition of low-birth-weight infants after the intestinal operation

• Project/Area Number: 23890187
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pediatric surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: MITANI Yasuyuki 和歌山県立医科大学, 医学部, 学内助教 (40612106)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 超低出生体重児 / 脂肪乳剤 / 肝障害 / 超出生体重児

Research Abstract

This research was done using the new composition preparations emulsified with PG (phosphatide compounded by epikuron200 and glycerol to phospholipase DM which is soy lecithin) which mixed MCT and LC in an equivalent amount of 1 to 1 as neutral fat 10%.Using four weeks of Wistar system age maleness rat, the self-sustaining intravenous dosage containing a new composition PG emulsification MCT/LCT agent was performed, and measurement of the neutral fat, phosphatide, HDL cholesterol, AST, ALT, direct, and indirect bilirubin value was performed. As a result, an impaired liver function was prominent at the medication speed of 1.2g/kg/hr and 1.8g/kg/hr, and it turned out that optimal speed is 0.6g/kg/hr.