Significance of epithelial-mesenchymal transition in Sj.gren's syndrome and a novel therapeutic approach
| Project/Area Number |
23890243
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
HIROMASA Kana 産業医科大学, 医学部, 助教 (00612384)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | シェーグレン症候群 / 上皮ー間葉転換 / DC-SIGN / 樹状細胞 / 上皮-間葉転換 / 唾液腺 / 汗腺 / 涙腺 |
|---|
| Research Abstract |
To evaluate a role of epithelial-mesenchymal transition (EMT) in Sjogren’s syndrome, we performed an immunohistochemistry, which revealed that EMT-inducing proteins, Snail1 and Twist1 were highly expressed in the skin and salivary glands of the patients. The numbers of CD209d(DC-SIGN) positive dendritic cells were increased both in mouse model for Sj.gren’s syndrome and human patients, paving a new therapeutic approach for this disease.
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Report
(3 results)
Research Products
(16 results)
