Neuroprotection and regeneration by retinal glia
| Project/Area Number |
23890254
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2011) |
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Principal Investigator |
HARADA Chikako 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (20435720)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | グリア / 神経保護 / 神経再生 / 神経栄養因子 / 視細胞 / 網膜神経節細胞 / 網膜 / Muller細胞 / 再生 |
|---|
| Research Abstract |
In this study, we prepared two conditional knockout mice, in which neurotrophic factor receptor (TrkB) is absent from retinal Muller glia or other neural cell types. By analyzing these mice, we found that neurotrophic factor signaling in glia is necessary for neuroprotection of surrounding retinal neurons and regeneration of glial cells into neural cells.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury.2013
Author(s)
Katome, T., Namekata, K., Guo, X., Semba, K., Kittaka, D., Kawamura, K., Kimura, A., Harada, C., Ichijo, H., Mitamura, Y. and Harada, T.
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Journal Title
Cell Death Differ.
Volume: 20
Issue: 2
Pages: 270-280
DOI
Related Report
Peer Reviewed
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[Journal Article] Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis2011
Author(s)
Guo, X., Harada, C., Namekata, K., Kimura, A., Mitamura, Y., Yoshida, H., Matsumoto, Y., and Harada, T
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Journal Title
Investigative Ophthalmology & Visual Science
Volume: 52(5)
Issue: 5
Pages: 2696-2703
DOI
Related Report
Peer Reviewed
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[Journal Article] Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma
Author(s)
Namekata, K., Kimura, A., Kawamura, K., Guo, X., Harada, C., Tanaka, K. and Harada, T
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Journal Title
Cell Death and Differentiation
Volume: (in press)
Related Report
Peer Reviewed
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