| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Age-related macular degeneration (AMD) is a leading cause of vision loss and blindness in the elderly. The dry form is more common and accounts for about 85~90% of AMD patients in US, while Japanese AMD patients predominantly progress to wet-form or polypoidal choroidal vasculopathy (PCV). Recent studies have shown HtrA1, a serine protease gene, as major risk factor for wet form AMD (DeWan et al., Science, 2006). Furthermore, we reported that Japanese typical wet form AMD patients show significant association with ARMS2/HtrA1 (rs10490924: p=4.1x10-14, OR=4.16) (Goto, et al., JOBDI, 2009). The purpose of study is to characterize promoter function of ARMS2 and HtrA1 genes in wet-form AMD.
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